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Table 1 Clinicopathological characteristics

From: Cystatin M loss is associated with the losses of estrogen receptor, progesterone receptor, and HER4 in invasive breast cancer

 

DCIS

IBC

 

Cystatin M loss

 

Cystatin M loss

 
 

Yes ( n = 9)

No ( n = 108)

P -value

Yes ( n = 99)

No ( n = 76)

P -value

Age1

50 ± 9

46 ± 9

0.13

49 ± 11

49 ± 10

0.89

Tumor size (cm)1

2.7 ± 1.8

3.0 ± 2.1

0.87

2.9 ± 1.3

2.6 ± 1.1

0.27

Number of LN1

0

0.4 ± 1.1

0.69

2.6 ± 5.0

3.1 ± 5.9

0.83

Family history

      

   No

9

104

 

92

72

 

   Yes

0

4

1.00

7

4

0.76

Histologic grade

      

   I

1

24

 

8

8

 

   II

5

48

 

42

39

 

   III

3

36

0.90

49

29

0.32

ER

      

   Negative

1

32

 

50

24

 

   Positive

8

76

0.44

49

52

0.01

PR

      

   Negative

3

42

 

62

30

 

   Positive

6

66

1.00

37

46

0.002

HER2

      

   Negative

3

46

 

58

43

 

   Positive

6

62

0.73

41

33

0.79

HER4

      

   Negative

7

37

 

34

11

 

   Positive

2

71

0.03

65

65

0.003

Stage

      

   I

   

21

14

 

   II

   

55

43

 

   III

   

22

18

 

   IV

   

1

2

0.86

  1. 1 Mean ± standard deviation.
  2. DCIS, ductal carcinoma in situ; IBC, invasive breast cancer; ER, estrogen receptor; PR, progesterone receptor; LN, number of involved lymph node; Family history, a history of breast cancer within family.