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Table 1 Limiting dilution tumor formation of parental, hypoxia-exposed adherent, and cycling hypoxia-selected breast cancer cells in vivo

From: Identification of a stem-like cell population by exposing metastatic breast cancer cell lines to repetitive cycles of hypoxia and reoxygenation

Cell type

Days

Number injected and tumors formed

  

5 × 105

5 × 104

5 × 103

5 × 102

MDA-MB 231 (total cell population)

24-90

5/6

2/6

0/5

0/5

MDA-MB 231 A3 (hypoxia-exposed adherent cells)

90

-

-

-

0/5

MDA-MB 231 F3 (cycling hypoxia-selected subpopulation)

10-90

6/6

6/6

5/5

4/5

BCM2 (total cell population)

35-98

-

5/5

-

0/5

BCM2 A3 (hypoxia-exposed adherent cells)

98

-

-

-

0/5

BCM2 F3 (cycling hypoxia-selected subpopulation)

28-98

-

5/5

-

4/5