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Table 2 WST-1 proliferation assay for BT474 cells treated with atRA and tamoxifen

From: Anti-tumor effects of retinoids combined with trastuzumab or tamoxifen in breast cancer cells: induction of apoptosis by retinoid/trastuzumab combinations

 

Fraction affected

 

Dose

atRA

Tamoxifen

atRA + Tam

Combination index

0.2

0.21 ± 0.012

0.16 ± 0.059

0.33 ± 0.015

0.53 ± 0.099

0.4

0.26 ± 0.075

0.23 ± 0.049

0.46 ± 0.020

0.27 ± 0.066

0.6

0.37 ± 0.026

0.29 ± 0.075

0.51 ± 0.035

0.24 ± 0.062

1

0.47 ± 0.043

0.33 ± 0.032

0.60 ± 0.027

0.16 ± 0.048

5

0.51 ± 0.067

0.42 ± 0.029

0.62 ± 0.050

0.64 ± 0.072

10

0.53 ± 0.071

0.59 ± 0.045

0.69 ± 0.050

0.61 ± 0.106

  1. Doses of all-trans retinoic acid (atRA) and tamoxifen (Tam) in μM. Each value is the mean of three independent experiments (with eight replicate wells for each treatment) ± standard error.