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Table 2 ORs and 95% CIs for CCL and breast cancer risk among participants with BBD

From: Columnar cell lesions and subsequent breast cancer risk: a nested case-control study

 

Cases

Controls

OR (95%CI)*

OR (95%CI)**

CCL status

    

   No CCL

254

1,158

1.0 (reference)

1.0 (reference)

   CCL

140

448

1.44 (1.14, 1.83)

1.37 (1.06, 1.76)

CCL status, adjusted for BBD histologic category

    

   No CCL

254

1,158

1.0 (reference)

1.0 (reference)

   CCL

140

448

1.20 (0.94, 1.54)

1.16 (0.89, 1.50)

Jointly classified BBD/CCL histologic category

    

   Nonproliferative, no CCL

80

518

1.0 (reference)

1.0 (reference)

   Nonproliferative, CCL

19

93

1.33 (0.77, 2.29)

1.24 (0.69, 2.22)

   Proliferative without atypia, no CCL

125

558

1.46 (1.08, 1.99)

1.38 (1.00, 1.91)

   Proliferative without atypia, CCL

74

277

1.81 (1.27, 2.58)

1.63 (1.12, 2.38)

   Atypical hyperplasia, no CCL

49

82

4.26 (2.75, 6.59)

4.04 (2.57, 6.36)

   Atypical hyperplasia, CCL

47

78

4.37 (2.81, 6.81)

4.20 (2.63, 6.70)

  1. OR indicates odds ratio; 95% CI, 95% confidence interval.
  2. *Adjusted for age, year of BBD diagnosis, and time since BBD biopsy.
  3. **Adjusted for the above-mentioned factors and body mass index at age 18, weight change between age 18 and diagnosis/index date, family history of breast cancer, postmenopausal hormone use, and jointly classified parity/age at first birth.