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Table 4 Association of Msx2 with cell cycle-associated and Msx2-interacting genes at the mRNA level within the Van de Vijver dataseta

From: Homeobox transcription factor muscle segment homeobox 2 (Msx2) correlates with good prognosis in breast cancer patients and induces apoptosis in vitro

Variable

Van de Vivjer data set (n= 295)

 
 

Low Msx2

(n= 74)

High Msx2

(n= 221)

P value

Association with

Prognosis?

Survivin

  

<0.001

Poor**

   Low

24 (32.4)

125 (56.6)

  

   High

50 (67.6)

96 (43.4)

  

Cyclin D1

  

<0.001

NS

Low

High

32 (43.2)

42 (56.8)

42 (19)

179 (81)

  

Cyclin A1

  

0.037

Poor**

   Low

49 (66.2)

173 (78.3)

  

   High

25 (33.8)

48 (21.7)

  

Cyclin A2

  

0.007

Poor**

   Low

27 (36.5)

121 (54.8)

  

   High

47 (63.5)

100 (45.2)

  

Cyclin B2

  

0.014

Poor**

   Low

28 (37.8)

120 (54.3)

  

   High

46 (62.2)

101 (45.7)

  

Cyclin E1

  

0.003

Poor**

   Low

46 (62.2)

175 (79.5)

  

   High

28 (37.8)

45 (20.5)

  

DLX5

  

0.077

Poor*

   Low

50 (67.6)

172 (77.8)

  

   High

24 (32.4)

49 (22.2)

  

BMP4

  

0.017

Good**

   Low

46 (62.2)

102 (46.2)

  

   High

28 (37.8)

119 (53.8)

  
  1. aBMP, bone morphogenetic protein; DLX5, distal-less homeobox 5; *P < 0.05 **P < 0.01 (log rank test); otherwise χ2 test.