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Table 1 Inter-observer and intra-observer agreement of breast cancer histological grade.

From: Breast cancer prognostic classification in the molecular era: the role of histological grade

Study

Number of cases

Number of readers

Grade

Inter-observer

[32]

613

2

NGS

Kappa 0.69

[8]

52

2

NGS

Kappa 0.54

[55]

425

2

NGS

Complete agreement 76%

[50]

75

6

NGS

Kappa 0.43 to 0.74

[51]

12

600

NGS

Kappa 0.45 to 0.53 (figures after application of guidelines)

[52]

 

3

NGS

Complete agreement 72.3%; kappa 0.57

[53]

24

21

NGS

Complete agreement 69%; kappa 0.53

[54]

50

5

NGS

Mean polychoric correlation 0.8

[56]

35

13

NGS

Kappa 0.5 to 0.7

[57]

93

7

NGS

Kappa 0.54

[58]

40

3

NGS

Kappa 0.68 to 0.83

[59]

874

2

WHO criteria

Complete agreement 78.1%; kappa 0.66

[61]

50

5

NGS

Complete agreement 83.3%; kappa 0.73

  1. NGS, Nottingham Grading System; WHO, World Health Organization.