Figure 3From: HER3 and downstream pathways are involved in colonization of brain metastases from breast cancer Oncocarta and validation mutation analyses. A). Example of NRAS Q61R mutation identified by OncoCarta in matched pair sample #7 showing representative spectra and cluster plot. B) Sequence validation of NRAS G12C, sample D6 - lung metastasis. C) Sequence validation of NRAS Q61R, breast and brain metastasis from sample #2. D) Immunohistochemistry of brain metastasis (sample D4) with antibody specific to EGFR E746_A750del showing staining in the tumor but not the surrounding brain tissue.Back to article page