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Figure 3 | Breast Cancer Research

Figure 3

From: HER3 and downstream pathways are involved in colonization of brain metastases from breast cancer

Figure 3

Oncocarta and validation mutation analyses. A). Example of NRAS Q61R mutation identified by OncoCarta in matched pair sample #7 showing representative spectra and cluster plot. B) Sequence validation of NRAS G12C, sample D6 - lung metastasis. C) Sequence validation of NRAS Q61R, breast and brain metastasis from sample #2. D) Immunohistochemistry of brain metastasis (sample D4) with antibody specific to EGFR E746_A750del showing staining in the tumor but not the surrounding brain tissue.

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