Skip to main content

Table 2 Combination Index of hormone drugs and taxanes

From: The estrogen receptor influences microtubule-associated protein tau (MAPT) expression and the selective estrogen receptor inhibitor fulvestrant downregulates MAPT and increases the sensitivity to taxane in breast cancer cells

 

Tamoxifen

 

Fulvestrant

 
 

Combination Index Values at

 

Combination Index Values at

 

Cell line

ED50 (Average ± SD)

ED75 (Average ± SD)

r

ED50 (Average ± SD)

ED75 (Average ± SD)

r

(Paclitaxel)

      

MCF7

1.38(0.26)

1.00(0.28)

0.97

0.55(0.28)

0.66(0.12)

0.97

ZR75-1

1.42(0.35)

1.04(0.09)

0.98

0.45(0.22)

0.56(0.32)

0.97

(Docetaxel)

      

MCF7

1.35(0.11)

0.91(0.16)

0.97

0.59(0.17)

0.53(0.14)

0.98

ZR75-1

1.33(0.37)

1.11(0.27)

0.97

0.53(0.31)

0.60(0.20)

0.98

  1. The CI values at ED50 and ED 75 in the MCF-7 and ZR 75-1 cell lines. The values are the average of four independent experiments, with the SD given in parentheses. Combination treatment with fulvestrant and taxanes showed a stronger synergistic effect than the combination treatment with tamoxifen and taxanes in both cell lines. C.I, Combination Index; SD, standard deviation.
Back to article page

Breast Cancer Research

ISSN: 1465-542X

Contact us