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Figure 1 | Breast Cancer Research

Figure 1

From: Cooperative signaling between Wnt1 and integrin-linked kinase induces accelerated breast tumor development

Figure 1

Overexpression of the human ILK gene. (a) Mouse MMTV-Wnt1 and human MMTV-ILK transgene constructs (b). Quantitative RT-PCR performed on randomly selected tumors from each MMTV-Wnt1 and MMTV-Wnt/ILK group (n = 8) showing a dramatic overexpression of the human ILK gene in the double-transgenic samples. The bar graphs show the relative amount of human ILK overexpression in the individual MMTV-Wnt/ILK and MMTV-Wnt1 tumors normalized for β-actin expression. The statistical analysis with 95% confidence interval of (+754.18; -256.46) shows an average value of about 400-fold of overexpression in human ILK in MMTV-Wnt/ILK with an adjusted P value of 3.1E-16 determined by Benjamini-Hochberg test.

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Breast Cancer Research

ISSN: 1465-542X

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