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Table 4 Breast cancer incidence in pre-, peri/postmenopausal and all women in relation to serum TSH levels

From: Prospectively measured triiodothyronine levels are positively associated with breast cancer risk in postmenopausal women

Group

TSH

(quartile)

Individuals

(n)

Breast cancer

cases

(n)

Person-years

Incidence/100,000

All cases

Cases >3 years following

Baseline examination

      

RR

(CI: 95%)

RR**

(CI: 95%)

RR

(CI: 95%)

RR**

(CI: 95%)

All

1

647

40

11,764

340

1.00

1.00

1.00

1.00

 

2

528

42

9,517

441

1.05 (0.70 to 1.58)

1.07 (0.71 to 1.62)

1.28 (0.81 to 2.01)

1.26 (0.80 to 1.97)

 

3

793

55

15,829

347

0.93 (0.62 to 1.41)

0.94 (0.62 to 1.42)

1.20 (0.77 to 1.87)

1.19 (0.76 to 1.85)

 

4

710

36

14,521

248

0.87 (0.55 to 1.37)

0.80 (0.50 to 1.27)

0.95 (0.57 to 1.57)

1.03 (0.62 to 1.69)

 

P-trend

    

0.46

0.29

0.82

0.94

Premenopausal

1

155

10

3,170

315

1.00

1.00

1.00

1.00

 

2

221

18

4,669

386

1.48 (0.76 to 2.90)

1.38 (0.69 to 2.77)

1.91(0.90 to 4.08)

2.02 (0.97 to 4.23)

 

3

329

28

6,869

408

0.95 (0.48 to 1.87)

0.94 (0.47 to 1.87)

1.31(0.62 to 2.79)

1.30 (0.62 to 2.72)

 

4

194

7

4,213

166

0.81 (0.36 to 1.86)

0.62 (0.26 to 1.46)

0.88 (0.35 to 2.21)

1.11 (0.46 to 2.67)

 

P-trend

    

0.42

0.20

0.64

0.91

Peri/post-menopausal

1

492

30

8,593

349

1.00

1.00

1.00

1.00

 

2

307

24

4,848

495

0.86 (0.51 to 1.45)

0.87 (0.51 to 1.47)

0.93 (0.52 to 1.67)

0.94 (0.53 to 1.67)

 

3

464

27

8,960

301

0.93 (0.56 to 1.56)

0.94 (0.56 to 1.58)

1.13 (0.65 to 1.98)

1.14 (0.66 to 1.99)

 

4

516

29

10,308

281

0.88 (0.51 to 1.53)

0.82 (0.47 to 1.43)

0.89 (0.48 to 1.65)

0.97 (0.53 to 1.78)

 

P-trend

    

0.73

0.57

0.94

0.87

  1. Abbreviations: TSH, thyrotropin; RR, relative risk; RR**, relative risk adjusted for age (continuous), menopausal status (in analysis of all women), use of HRT, nulliparity, use of oral contraception, age at menarche, smoking status, alcohol consumption, BMI, height, educational level and marital status. * P < 0.05.