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Table 1 Relative expression of DNA repair and cell cycle proteins in MCF-7 monolayer and mammosphere populations

From: Senescence evasion by MCF-7 human breast tumor-initiating cells

Protein Dose(Gy) Normalized band intensity (n = 3) P value
   Monolayer Mammosphere  
APE1 0 1.00 2.10 0.024
  1 1.02 1.92 0.052
  10 1.07 1.84 0.017
ATM 0 1.00 1.99 0.018
  1 1.13 2.23 0.011
  10 1.62 1.99 0.088
p21 0 1.00 0.04 0.001
  1 1.16 1.04 0.207
  10 1.17 1.11 0.310
Chk1 0 1.00 2.17 0.003
  1 1.03 2.06 0.018
  10 1.05 2.31 0.052
phospho-Chk1 0 1.00 0.92 0.116
  1 1.13 0.80 0.027
  10 1.08 0.85 0.006
Chk2 0 1.00 2.39 0.001
  1 0.92 2.46 0.001
  10 0.93 2.51 0.005
phospho-Chk2 0 1.00 0.69 0.034
  1 0.91 0.64 0.030
  10 0.84 0.91 0.180
  1. APE1, apurinic/apyrimidinic endonuclease 1; ATM, ataxia telangiectasia mutated; phospho-Chk1, Chk1 phosphorylated at Ser345; phospho-Chk2, Chk2 phosphorylated at Thr68.