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Figure 3 | Breast Cancer Research

Figure 3

From: Breast cancer-specific mutations in CK1ε inhibit Wnt/β-catenin and activate the Wnt/Rac1/JNK and NFAT pathways to decrease cell adhesion and promote cell migration

Figure 3

Homology model of the catalytic domain of casein kinase 1 epsilon mutants. Three-dimensional representation of a homology model of the catalytic domain of casein kinase 1 epsilon (CK1ε) (residues 1 to 295). Phylogenetically conserved functional sites across the serine/threonine kinase superfamily are indicated: pink, substrate binding pocket; yellow, ATP binding site; red, catalytic loop; blue, activation loop. The individual point mutations that were found in patients (a) P6 (L39Q), (b) P3 (L39Q, S101R), and (c) P4 (L39Q, L49Q, N78T) are indicated in orange. (d) A mutation cluster region in P4. The mutations and ATP binding region are indicated in orange and yellow, respectively. A blue sphere indicates a predicted autophosphorylation site (Thr 44).

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