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Figure 9 | Breast Cancer Research

Figure 9

From: Novel design principles enable specific targeting of imaging and therapeutic agents to necrotic domains in breast tumors

Figure 9

In Vivo inhibition of STL-6014 accumulation in small orthotopic human breast MDA-MB-231-RFP tumors by c(RGDfK). (a) CD-1 nude, female mice bearing orthotopically grafted MDA-MB-231-RFP (n = 3) were intravenously injected with 140 nmol STL-6014. (b) CD-1 nude, female mice bearing orthotopically grafted MDA-MB-231-RFP (n = 3) were intravenously injected with 8.5 μmol c(RGDfK) and one hour later with 140 nmol STL-6014. Fluorescent images were taken at the indicated times post-injection. Upper panel - near infrared (NIR) fluorescence images indicate bacteriochlorophyll derivative (Bchl-D) distribution, lower panel - red fluorescence images indicate tumor size and location. All other details are as described in the methods section.

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