Table 4 Multivariable cox regression model for DFS
Gene/Clinical | Comparison | Adjusted DFS | |
|---|---|---|---|
| Â | Â | HR (95% CI) | Wald P-value |
CYP2B6 | Any variant vs. All WT | 1.06 (0.77, 1.46) | 0.72 |
CYP2C9 | Any variant vs. All WT | 1.11 (0.80, 1.53) | 0.53 |
CYP2D6 | G/A vs. A/A | 0.94 (0.46, 1.94) | 0.87 |
| Â | G/G vs. A/A | 0.99 (0.50, 1.99) | 0.99 |
CYP3A4 | *1B/*1A vs. *1A/*1A | 2.79 (1.52, 5.14) | 0.001 |
| Â | *1B/*1B vs *1A/*1A | 2.67 (0.86, 8.34) | 0.09 |
CYP3A5 | *3/*1 vs. *1/*1 | 1.18 (0.47, 2.98) | 0.72 |
| Â | *3/*3 vs. *1/*1 | 2.09 (0.79, 5.50) | 0.14 |
CYP3A5 | *6/*1 vs. *1/*1 | 1.37 (0.39, 4.79) | 0.62 |
GSTM1 | Null vs. Non-null | 0.78 (0.57, 1.06) | 0.12 |
GSTT1 | Null vs. Non-null | 1.32 (0.86, 2.01) | 0.21 |
GSTP1 | Any Var vs. All WT | 0.94 (0.69, 1.28) | 0.69 |
Lymph node | Continuous | 1.02 (1.00, 1.04) | 0.03 |
Tumor size | Continuous | 1.00 (0.97, 1.01) | 0.46 |
Age | Continuous | 0.99 (0.97, 1.01) | 0.46 |
ER | Pos vs. Neg | -- | -- |
PR | Pos vs. Neg | 1.01 (0.69, 1.50) | 0.95 |
Race | Black vs. White | 1.08 (0.52, 2.25) | 0.84 |
| Â | Other vs. White | 1.84 (0.91, 3.70) | 0.09 |
Arm | CAF+HDC vs. CAF | 0.66 (0.48, 0.91) | 0.01 |