SNP | Variants | Genotypes | White # (%) (n = 314) | Black # (%) (n = 19) | Other # (%) (n = 17) | P-value1 |
---|---|---|---|---|---|---|
CYP2B6 | All WT | 516 G/G | 114 (36) | 4 (21) | 4 (23) | 0.14 |
(rs2279343, | Â | 785 A/A | Â | Â | Â | Â |
rs3211371, | Â | 1459 C/C | Â | Â | Â | Â |
rs3745274) | Any Var | Any Var | 189 (60) | 15 (79) | 11 (65) | Â |
 | Missing |  | 11 (4) | 0 (0) | 2 (12) |  |
CYP2C9 | All Wild- | 430 C/C | 176 (56) | 17 (89) | 9 (53) | 0.06 |
(rs1799853, | type | 1075 A/A | Â | Â | Â | Â |
rs1057910) | Any Var | Any Var | 107 (34) | 2 (11) | 7 (41) | Â |
 | Missing |  | 31 (10) | 0 (0) | 1 (6) |  |
CYP2D6*4 | *1/*1 | A/A | 19 (6) | 0 (0) | 0 (0) | 0.81 |
(rs3892097) | *1/*4 | G/A | 86 (27) | 4 (21) | 4 (27) | Â |
 | *4/*4 | G/G | 198 (63) | 15 (79) | 11 (63) |  |
 | Missing |  | 11 (4) | 0 (0) |  |  |
CYP3A4*1B | *1A/*1A | A/A | 281 (89) | 5 (26) | 13 (76) | <0.001 |
(rs2740574) | *1A/*1B | G/A | 20 (6) | 7 (37) | 2 (12) | Â |
 | *1B/*1B | G/G | 3 (1) | 7 (37) | 0 (0) |  |
 | Missing |  | 10 (3) | 0 (0) | 2 (12) |  |
CYP3A5*3 | *1/*1 | A/A | 4 (1) | 9 (47) | 0 (0) | <0.001 |
(rs776746) | *1/*3 | G/A | 39 (12) | 8 (42) | 5 (29) | Â |
 | *3/*3 | G/G | 260 (83) | 1 (5) | 11 (65) |  |
 | Missing |  | 11 (4) | 1 (5) | 1 (6) |  |
CYP3A5*6 | *1/*1 | G/G | 307 (98) | 15 (79) | 16 (94) | <0.001 |
(rs10264272) | *1/*6 | A/G | 1 (<1) | 4 (21) | 0 (0) | Â |
 | *6/*6 | A/A | 0 (0) | 0 (0) | 0 (0) |  |
 | Missing |  | 6 (2) | 0 (0) | 1 (6) |  |
GSTM1 | Non-null | Â | 135 (43) | 11 (58) | 9 (53) | 0.09 |
 | Null |  | 171 (54) | 7 (37) | 6 (35) |  |
 | Missing |  | 8 (3) | 1 (5) | 2 (12) |  |
GSTT1 | Non-null | Â | 254 (81) | 10 (53) | 13 (76) | 0.02 |
 | Null |  | 51 (16) | 8 (42) | 2 (12) |  |
GSTT1 | Missing | Â | 9 (3) | 1 (5) | 2 (12) | Â |
GSTP1 | All WT | Ex 5-24A/A | 146 (47) | 6 (32) | 7 (41) | 0.11 |
(rs1695, rs1138272) | Â | Ex 6+5 C/C | Â | Â | Â | Â |
 | Any Var | Any Variant | 160 (51) | 13 (68) | 8 (47) |  |
 | Missing |  | 8 (3) | 0 (0) | 2 (1) |  |
Combined CYP-GST genotype | Favorable | Â | 0 (0) | 0 (0) | 0 (0) | 0.06 |
groups | Intermediate | Â | 186 (60) | 15 (79) | 6 (35) | Â |
 | Unfavorable |  | 102 (32) | 3 (16) | 8 (47) |  |
 | Missing |  | 26 (8) | 1 (5) | 3 (18) |  |