From: Gene therapy for carcinoma of the breast: Genetic toxins
Enzyme | Prodrug | Cytotoxic product |
---|---|---|
Herpes simplex virus thymidine kinase | Ganciclovir | Ganciclovir triphosphate |
Cytosine deaminase | 5-Fluorocytosine | 5-Fluorouracil |
Varicella zoster virus thymidine kinase | 6-Methoxypurine arabinose | Adenine arabinonucleoside triphosphate |
Nitroreductase | CB1954 | 5-Aziridinyl-4-hydroxylamino-2-nitrobenzamide |
Cytochrome p450 | Cyclophosphamide | Acrolein and phosphoramide mustard |
Thymidine phosphorylase | 5' -Deoxy-5-fluorouridine | 5-Fluorouracil |
Purine nucleoside phosphorylase | 6-Methylpurine-deoxyriboside | 6-Methylpurine |
Alkaline phosphatase | Etoposide phosphate | Etoposide |
Carboxypeptidase A | Methotrexate-alanine | Methotrexate |
Carboxypeptidase G2 | Benzoic acid mustard-glucuronide | Benzoic acid mustard |
Linamarase | Linamarin | Cyanide |
Xanthine oxidase | Xanthine | Oxygen radicals |
β -Lactamase | Cephalosporin-mustard-carbamate | Nitrogen mustard |