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Table 2 Comparison of pathologic characteristics of ER-negative and ER-positive BRCA1-associated breast cancers

From: Estrogen receptor positive breast cancers in BRCA1 mutation carriers: clinical risk factors and pathologic features

Covariates

ER-

ER+

Logistic likelihood ratio test P

 

n

%

n

%

 

All

68

 

49

  

Histologic type

     

   Invasive ductal only *

67

99

37

76

<0.001

   Other

1

1

12

24

 

   Mixed ductal/lobular

1

 

10

  

   Tubular

0

 

1

  

   Lobular

0

 

1

  

Histologic grade

     

   3 *

66

97

20

41

<0.001

   1-2

2

3

28

57

 

   Unknown (combined with 1-2)

0

0

1

2

 

Mitotic activity

     

   >10 mitoses per 10 HPF *

64

94

11

22

<0.001

   0-10 mitoses per 10 HPF

4

6

37

76

 

   Unknown

0

0

1

2

 

Margins

     

   Invasive *

22

32

44

90

<0.001

   Pushing

41

60

4

8

 

   Unknown

5

7

1

2

 

Lymphocytic infiltrate

     

   Moderate/marked *

20

29

3

6

0.003

   None/mild

46

68

45

92

 

   Unknown *

2

3

1

2

 

Geographic necrosis/fibrotic focus

     

   Yes *

50

74

8

16

<0.001

   No

15

22

39

80

 

   Unknown *

3

4

2

4

 

Age of breast cancer

     

   Median (range)

39.5 (28-73)

 

45 (29-72)

  

   <40

34

50

15

31

0.03

   40-49

27

40

20

41

0.91

   ≥ 50

7

10

14

29

0.01

  1. ER, estrogen receptor; HPF, high-powered field; -, negative; +, positive.
  2. Percentages calculated by column
  3. (*) indicates this level of the covariate was included in the single covariate model