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Table 6 Association between YY1 nuclear protein expression with HER-2 gene and protein expression levels

From: Investigating AP-2 and YY1 protein expression as a cause of high HER2 gene transcription in breast cancers with discordant HER2 gene amplification

   YY1
   Negative Positive χ2 P-value
HER-2 Gene Expression Normal 315 (40.6%) 190 (49.4%) 13.115 0.004
  Amplified 68 (8.8%) 16 (4.2%)   
  Gain 13 (1.7%) 7 (1.8%)   
HER-2 Protein Expression 0 366 (67.3%) 178 (32.7%) 19.882 <0.001
  1+ 13 (39.4%) 20 (60.6%)   
  2+ 21 (4.7%) 7 (3.3%)   
  3+ 51 (11.3%) 10 (4.7%)   
  1. Significance level P = 0.05.