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Table 5 Association between AP-2 protein expression and HER-2 status

From: Investigating AP-2 and YY1 protein expression as a cause of high HER2 gene transcription in breast cancers with discordant HER2 gene amplification

   AP-2 (α and β isoforms) AP-2 (α isoform)
   Negative Positive χ2 P-value Negative Positive χ2 P-value
HER-2
Gene
Expression
Normal 459 (76.4%) 142 (23.6%) 2.782 0.249 217
(53.6%)
188 (46.4%) 2.664 0.446
  Amplified 60 (76.9%) 18 (23.1%)    31 (49.2%) 32 (50.8%)   
  Gain 21 (91.3%) 2 (8.7%)    15 (46.9%) 17
(53.1%)
  
HER-2
Protein
Expression
0 435 (78.4%) 120 (21.6%) 5.427 0.143 237
(55.4%)
191
(44.6%)
8.550 0.032
  1+ 21 (61.8%) 13 (38.2%)    62
(66.6)
31
(33.3)
  
  2+ 21
(80.8%)
5 (19.2%)    17
(60.7%)
11
(39.3%)
  
  3+ 51 (79.7%) 13 (20.3%)    37
(45.1%)
45
(54.9%)
  
  1. Two different AP-2 antibodies were used; one recognised AP-2α and β isoforms while the other recognised only the AP-2α isoform. Significance level P = 0.05.