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Table 4 The association of YY1 protein levels were compared with cancer relevant biomarkers in breast tumours

From: Investigating AP-2 and YY1 protein expression as a cause of high HER2 gene transcription in breast cancers with discordant HER2 gene amplification

  YY1   
Biomarker Negative Positive χ2 P-value
ER     
Negative 248 (34.4) 64 (17.9) 31.912 <0.001
Positive 472 (65.6) 294 (82.1)   
PgR     
Negative 358 (49.9) 120 (33.7) 25.343 <0.001
Positive 359 (50.1) 236 (66.3)   
CK19     
Negative 77 (10.4) 24 (6.6) 4.370 0.037
Positive 661 (89.6) 341 (93.4)   
HER3     
Negative 68 (11.1) 37 (12.5) 0.388 0.534
Positive 543 (88.9) 258 (87.5)   
HER4     
Negative 104 (16.9) 85 (28.7) 16.938 <0.001
Positive 511 (83.1) 211 (71.3)   
E-cadherin     
Negative 294 (40.8) 127 (35.2) 3.170 0.075
Positive 427 (59.2) 234 (64.8)   
EGFR     
Negative 503 (79.7) 251 (81.0) 0.205 0.651
Positive 128 (20.3) 59 (19.0)   
CK5/6     
Negative 599 (80.6) 315 (86.5) 5.947 0.015
Positive 144 (19.4) 49 (13.5)   
CK14     
Negative 623 (85.3) 325 (90.3) 5.183 0.023
Positive 107 (14.7) 35 (9.7)   
P53     
Negative 508 (70.2) 281 (78.9) 9.318 0.002
Positive 216 (29.8) 75 (21.1)   
Mib1     
Negative 168 (41.7) 91 (51.1) 4.450 0.035
Positive 235 (58.3) 87 (48.9)   
Bcl2     
Negative 230 (38.9) 72 (24.3) 18.556 <0.001
Positive 362 (61.1) 224 (75.7)   
  1. ER = oestrogen receptor; PgR = Progesterone receptor; CK- = Cytokeratin; EGFR = epidermal growth factor receptor.