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Table 4 The association of YY1 protein levels were compared with cancer relevant biomarkers in breast tumours

From: Investigating AP-2 and YY1 protein expression as a cause of high HER2 gene transcription in breast cancers with discordant HER2 gene amplification

 

YY1

  

Biomarker

Negative

Positive

χ2

P-value

ER

    

Negative

248 (34.4)

64 (17.9)

31.912

<0.001

Positive

472 (65.6)

294 (82.1)

  

PgR

    

Negative

358 (49.9)

120 (33.7)

25.343

<0.001

Positive

359 (50.1)

236 (66.3)

  

CK19

    

Negative

77 (10.4)

24 (6.6)

4.370

0.037

Positive

661 (89.6)

341 (93.4)

  

HER3

    

Negative

68 (11.1)

37 (12.5)

0.388

0.534

Positive

543 (88.9)

258 (87.5)

  

HER4

    

Negative

104 (16.9)

85 (28.7)

16.938

<0.001

Positive

511 (83.1)

211 (71.3)

  

E-cadherin

    

Negative

294 (40.8)

127 (35.2)

3.170

0.075

Positive

427 (59.2)

234 (64.8)

  

EGFR

    

Negative

503 (79.7)

251 (81.0)

0.205

0.651

Positive

128 (20.3)

59 (19.0)

  

CK5/6

    

Negative

599 (80.6)

315 (86.5)

5.947

0.015

Positive

144 (19.4)

49 (13.5)

  

CK14

    

Negative

623 (85.3)

325 (90.3)

5.183

0.023

Positive

107 (14.7)

35 (9.7)

  

P53

    

Negative

508 (70.2)

281 (78.9)

9.318

0.002

Positive

216 (29.8)

75 (21.1)

  

Mib1

    

Negative

168 (41.7)

91 (51.1)

4.450

0.035

Positive

235 (58.3)

87 (48.9)

  

Bcl2

    

Negative

230 (38.9)

72 (24.3)

18.556

<0.001

Positive

362 (61.1)

224 (75.7)

  
  1. ER = oestrogen receptor; PgR = Progesterone receptor; CK- = Cytokeratin; EGFR = epidermal growth factor receptor.