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Table 2 Association of two AP-2 isoforms with cancer relevant biomarkers

From: Investigating AP-2 and YY1 protein expression as a cause of high HER2 gene transcription in breast cancers with discordant HER2 gene amplification

  AP-2 (α and β isoforms) AP-2 (α isoform)
Biomarker Negative
(%)
Positive
(%)
χ2 P-value Negative Positive χ2 P-value
ER         
Negative 293 (34.6) 45 (18.5) 22.70 <0.001 248 (34.4) 102 (26.0) 5.287 0.02
Positive 555 (65.4) 198 (81.5)    472 (65.6) 291 (74.0)   
PgR         
Negative 410 (48.3) 72 (30.0) 25.524 <0.001 358 (49.9) 173 (44.0) 0.514 0.473
Positive 438 (51.7) 168 (70.0)    359 (50.1) 220 (56.0)   
CK19         
Negative 87
(10.0)
11
(4.5)
7.349 0.007 63
(12.6)
31
(7.7)
5.811 0.016
Positive 785 (90.0) 236 (95.5)    436 (87.4) 372 (92.3)   
HER3         
Negative 77
(10.7)
24 (11.9) 0.222 0.638 40
(9.4)
20
(5.7)
3.730 0.053
Positive 642 (89.3) 178 (88.1)    387 (90.6) 333 (94.3)   
HER4         
Negative 131 (18.3) 60 (29.1) 11.491 0.001 82
(19.0)
39 (11.3) 8.776 0.003
Positive 586 (81.7) 146 (70.9)    349 (81.0) 307 (88.7)   
E-cadherin         
Negative 345 (40.5) 85 (34.6) 2.871 0.09 179 (36.3) 142 (35.7) 0.038 0.846
Positive 506 (59.5) 161 (65.4)    314 (63.7) 256 (64.3)   
EGFR         
Negative 582 (78.9) 182 (85.0) 4.004 0.045 361 (80.6) 286 (78.4) 0.612 0.434
Positive 156 (21.1) 32
(15)
   87
(19.4)
79 (21.6)   
CK5/6         
Negative 713 (81.5) 224 (88.9) 7.65 0.006 399 (79.3) 346 (86.3) 7.457 0.006
Positive 162 (18.5) 28 (11.1)    104 (20.7) 55 (13.7)   
CK14         
Negative 736 (85.5) 233 (94.0) 6.456 0.011 426 (86.8) 361 (90.9) 3.787 0.052
Positive 125 (14.5) 15
(6.0)
   65
(13.2)
36
(9.1)
  
P53         
Negative 620 (72.6) 189 (77.8) 2.62 <0.106 328 (66.8) 294 (74.1) 5.504 0.019
Positive 234 (27.4) 54 (22.2)    163 (33.2) 103 (25.9)   
Mib1         
Negative 189 (43.0) 76 (56.7) 7.827 0.005 95
(34.2)
100 (50.5) 12.755 <0.001
Positive 251 (57.0) 58 (43.3)    183 (65.8) 98 (49.5)   
Bcl2         
Negative 43
(12.8)
7
(6.0)
4.139 0.042 18
(9.8)
24 (13.2) 1.044 0.307
Positive 292
(87.2)
110 (94.0)    166 (90.2) 158 (86.8)   
  1. ER: oestrogen receptor; PgR: Progesterone receptor; CK-: Cytokeratin; EGFR: epidermal growth factor receptor.