Table 2 Association of two AP-2 isoforms with cancer relevant biomarkers

Biomarker

Negative

(%)

Positive

(%)

χ²

P-value

Negative

Positive

χ²

P-value

ER

Negative

293 (34.6)

45 (18.5)

22.70

<0.001

248 (34.4)

102 (26.0)

5.287

0.02

Positive

555 (65.4)

198 (81.5)

472 (65.6)

291 (74.0)

PgR

Negative

410 (48.3)

72 (30.0)

25.524

<0.001

358 (49.9)

173 (44.0)

0.514

0.473

Positive

438 (51.7)

168 (70.0)

359 (50.1)

220 (56.0)

CK19

Negative

87

(10.0)

11

(4.5)

7.349

0.007

63

(12.6)

31

(7.7)

5.811

0.016

Positive

785 (90.0)

236 (95.5)

436 (87.4)

372 (92.3)

HER3

Negative

77

(10.7)

24 (11.9)

0.222

0.638

40

(9.4)

20

(5.7)

3.730

0.053

Positive

642 (89.3)

178 (88.1)

387 (90.6)

333 (94.3)

HER4

Negative

131 (18.3)

60 (29.1)

11.491

0.001

82

(19.0)

39 (11.3)

8.776

0.003

Positive

586 (81.7)

146 (70.9)

349 (81.0)

307 (88.7)

E-cadherin

Negative

345 (40.5)

85 (34.6)

2.871

0.09

179 (36.3)

142 (35.7)

0.038

0.846

Positive

506 (59.5)

161 (65.4)

314 (63.7)

256 (64.3)

EGFR

Negative

582 (78.9)

182 (85.0)

4.004

0.045

361 (80.6)

286 (78.4)

0.612

0.434

Positive

156 (21.1)

32

(15)

87

(19.4)

79 (21.6)

CK5/6

Negative

713 (81.5)

224 (88.9)

7.65

0.006

399 (79.3)

346 (86.3)

7.457

0.006

Positive

162 (18.5)

28 (11.1)

104 (20.7)

55 (13.7)

CK14

Negative

736 (85.5)

233 (94.0)

6.456

0.011

426 (86.8)

361 (90.9)

3.787

0.052

Positive

125 (14.5)

15

(6.0)

65

(13.2)

36

(9.1)

P53

Negative

620 (72.6)

189 (77.8)

2.62

<0.106

328 (66.8)

294 (74.1)

5.504

0.019

Positive

234 (27.4)

54 (22.2)

163 (33.2)

103 (25.9)

Mib1

Negative

189 (43.0)

76 (56.7)

7.827

0.005

95

(34.2)

100 (50.5)

12.755

<0.001

Positive

251 (57.0)

58 (43.3)

183 (65.8)

98 (49.5)

Bcl2

Negative

43

(12.8)

7

(6.0)

4.139

0.042

18

(9.8)

24 (13.2)

1.044

0.307

Positive

292

(87.2)

110 (94.0)

166 (90.2)

158 (86.8)