Table 2 List of genes located in the minimal common region of amplification at 13q34
Gene Name* | Reference Sequence | Chromosome location (start pb - end pb)** | Name | Additional information |
|---|---|---|---|---|
ANKRD10 | NM 017664 | 111530888-111567416 | ankyrin repeat domain 10 | |
ARHGEF7 | NM 145735.2 | 111767624-111947542 | Rho guanine nucleotide exchange factor (GEF) 7 | Rho GTPase |
C13orf16 | NM 152324.1 | 111973015-111996593 | chromosome 13 open reading frame 16 | |
SOX1 | NM 005986.2 | 112721913-112726020 | SRY (sex determining region Y)-box 1 | Transcription factor involved in the regulation of embryonic development and in the determination of the cell fate |
C13orf28 | NM 145248.3 | 113030669-113089001 | chromosome 13 open reading frame 28 | |
TUBGCP3 | NM 006322.4 | 113139328-113242481 | tubulin, gamma complex associated protein 3 | |
C13orf35 | NM 207440.1 | 113301358-113338811 | chromosome 13 open reading frame 35 | |
ATP11A | NM 032189.3 | 113344643-113541480 | ATPase, class VI, type 11A | Integral membrane ATPase |
MCF2L | NM 001112732.1 | 113622757-113752862 | MCF.2 cell line derived transforming sequence-like | |
F7 | NM 000131.3 | 113760105-113774994 | coagulation factor VII (serum prothrombin conversion accelerator) | Coagulation factor. Defects in this gene can cause coagulopathy |
F10 | NM 000504.3 | 113777113-113803841 | coagulation factor X | Coagulation factor. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity. |
PROZ | NM 003891.1 | 113812968-113826694 | protein Z, vitamin K-dependent plasma glycoprotein | |
PCID2 | NM 018386.2 | 113831925-113863029 | PCI domain containing 2 | |
CUL4A | NM 001008895.1 | 113863931-113919391 | cullin 4A | |
LAMP1 | NM 005561.3 | 113951469-113977741 | lysosomal-associated membrane protein 1 | Membrane glycoprotein. It may also play a role in tumor cell metastasis |
GRTP1 | NM 024719.2 | 113978506-114018463 | growth hormone regulated TBC protein 1 | |
ADPRHL1 | NM 138430.3 | 114076586-114107839 | ADP-ribosylhydrolase like 1 | Reversible posttranslational modification used to regulate protein function |
DCUN1D2 | NM 001014283.1 | 114110134-114145023 | DCN1, defective in cullin neddylation 1, domain containing 2 (S. cerevisiae) | |
TMCO3 | NM 017905.4 | 114145308-114204542 | transmembrane and coiled-coil domains 3 | |
TFDP1 | NM 007111.4 | 114239056-114295786 | transcription factor Dp-1 | Transcription factor that heterodimerizes with E2F proteins to enhance their DNA-binding activity and promote transcription from E2F target genes. |
ATP4B | NM 000705.2 | 114303123-114312501 | ATPase, H+/K+ exchanging, beta polypeptide | Encodes the beta subunit of the gastric H+, K+-ATPase |
GRK1 | NM 002929.2 | 114321597-114438636 | G protein-coupled receptor kinase 1 | Ser/Thr protein kinase that phosphorylates rhodopsin and initiates its deactivation. Defects in GRK1 are known to cause Oguchi disease 2 |
LOC100130386 | NR 028064.1 | 114451484-114454062 | hypothetical protein LOC100130386 | |
GAS6 | NM 000820.2 | 114523524-114567046 | growth arrest-specific 6 | Gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation, and may play a role in thrombosis |
FLJ44054 | NR 024609.1 | 114586610-114626485 | hypothetical protein LOC643365 | |
RASA3 | NM 007368.2 | 114747195-114898095 | RAS p21 protein activator 3 | Member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. |
CDC16 | NM 003903.3 | 115000362-115038150 | cell division cycle 16 homolog (S. cerevisiae) | Component protein of the APC complex, a cyclin degradation system that governs exit from mitosis |
UPF3A | NM 080687.1 | 115047078-115071281 | UPF3 regulator of nonsense transcripts homolog A (yeast) | Component of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance |
ZNF828 | NM_032436.2 | 115079965-115092802 | zinc finger protein 828 |