From: Altered serotonin physiology in human breast cancers favors paradoxical growth and cell survival
Study Type | Receptor Type | Variable | Direction of Change | P-value (T-test) | Oncomine data source |
---|---|---|---|---|---|
Tumor grade/stage | HTR2B | Normal vs Breast Carcinoma | Higher in Cancer | 0.002 | Richardson et. al. [77] |
 |  | Tumor stage N0-N3 | Increase with stage | 0.006 | Bittner et. al. [78] |
 | HTR2C | Tumor stage N0-N3 | Increase with stage | 0.009 | Yu et. al. [79] |
 | HTR7 | Grade I to III | Increase with grade | <0.0001 | Ivshina et. al. [80] |
 |  |  |  | 0.0001 | Miller et. al. [81] |
 |  |  |  | <0.01 | Ginestier C et. al. [82] |
More aggressive vs Less aggressive breast cancers | HTR1F | 5 yrs recurrence- vs 5 yrs recurrence+ | Higher in recurring tumors | 0.005 | VantVeer et. al. [83] |
 | HTR2B | Lymph node- vs Lymph node+ | Higher in lymph node + | 0.006 | Chin et. al. [84] |
 | HTR2C | Primary vs Metastatic tumors | Higher in metastatic | 0.001 | Bittner et. al. [78] |
 |  | Her2/neu- vs Her2/neu+ | Higher in Her2/neu+ | 0.00057 | Minn et. al. [85] |
 |  |  |  | 0.002 | Hess KR et. al. [86] |
 | HTR5A | P53-mutant vs p53-WT | Higher in p53-mutant | <0.0001 | Miller et. al. [81] |
 | HTR7 | P53-mutant vs p53-WT | Higher in p53-mutant | 0.008 | Miller et. al. [81] |
Steroid receptor status | HTR1F | ER+ vs ER- | Higher in ER+ | 0.0001 | Sotiriou et. al. [87] |
 | HTR2B | ER+ vs ER- | Higher in ER+ | 0.00014 | Wang et. al. [88] |
 |  |  |  | 0.0004 | Sotitiou et. al. [87] |
 |  |  |  | 0.00014 | Desmedt et. al. [89] |
 |  | Luminal vs Basal Tumors | Lower in Basal (ER-) | <0.0001 | Farmer et. al. [90] |
 | HTR4 | ER+ vs ER- | Higher in ER+ | 0.001 | Chi et. al. [84] |
 | HTR7 | ER+ vs ER- | Higher in ER+ | <0.0001 | VanderVijer et. al. [91] |
 |  |  |  | 0.00087 | Bittner et. al. [78] |
Human Mammary Cell lines | HTR2B | HMEC-Normal (GFP) vs c-Myc transformation | Higher in c-Myc transformed cells | 0.001 | Bild AH et. al. [92] |
 | HTR7 | HMEC-Normal (GFP) vs activated H-Ras | Higher in H-Ras cells | 0.00028 | Bild AH et. al. [92] |