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Table 2 Final model for multivariate analysis of MFS in all patients 1

From: Distinct inherited metastasis susceptibility exists for different breast cancer subtypes: a prognosis study

Characteristic HR (95% CI) P
Age (years)   
   41-55 vs. ≤ 40 0.88 (0.71-1.10) 0.265
   56-70 vs. ≤ 40 0.70 (0.5-0.98) 0.036
   >70 vs. ≤ 40 0.62 (0.43-0.90) 0.013
Menopausal status   
   Post vs. premenopausal 1.30 (1.01-1.67) 0.045
Lymph nodes involved   
   1-3 vs. 0 1.80 (1.49-2.18) < 0.001
   >3 vs. 0 2.73 (2.29-3.25) < 0.001
Tumor size   
   pT2 vs. pT1 1.56 (1.32-1.86) < 0.001
   pT3/4 vs. pT1 1.84 (1.44-2.36) < 0.001
Grade   
   Good/moderate vs. poor 0.56 (0.43-0.72) < 0.001
   Unknown vs. poor 0.91 (0.77-1.06) 0.221
ER   
   Positive vs. negative 0.79 (0.65-0.96) 0.016
PR   
   Positive vs. negative 0.82 (0.69-0.98) 0.032
RRP1B rs9306160   
   CT+TT vs. CC 0.83 (0.71-0.96) 0.012
SIPA1 rs2448490   
   GG+GA vs. AA 0.85 (0.69-1.05) 0.129
  1. 11725 patients
  2. CI = confidence interval; ER = estrogen receptor; HR = hazard ratio; MFS = metastasis-free survival; PR = progesterone receptor.