Skip to main content

Table 1 Genotype distributions by patient and tumor characteristics

From: Distinct inherited metastasis susceptibility exists for different breast cancer subtypes: a prognosis study

   SIPA1 rs2448490 RRP1B rs9306160
   GG AG AA CC CT TT
Characteristic Patients n (%) n (%) n (%) n (%) n (%) n (%)
Total 18631 748 (40) 807 (43) 293 (16) 616 (33) 904 (49) 333 (18)
Age (years)              
   ≤40 239 98 (41) 98 (41) 43 (18) 82 (34) 123 (51) 34 (14)
   41-55 736 301 (41) 323 (44) 103 (14) 235 (32) 359 (49) 139 (19)
   56-70 597 228 (39) 265 (45) 98 (17) 193 (33) 285 (48) 114 (19)
   >70 291 121 (42) 121 (42) 49 (17) 106 (37) 137 (47) 46 (16)
   P = 0.661 P = 0.481
Menopausal status              
   Premenopausal 823 334 (41) 364 (45) 117 (14) 268 (33) 419 (51) 135 (16)
   Postmenopausal 1040 414 (40) 443 (43) 176 (17) 348 (34) 485 (47) 198 (19)
   P = 0.288 P = 0.165
Lymph nodes involved              
   0 1095 441 (41) 459 (42) 183 (17) 358 (33) 535 (49) 192 (18)
   1-3 350 134 (38) 165 (47) 50 (14) 107 (31) 180 (51) 63 (18)
   >3 418 173 (42) 183 (44) 60 (14) 151 (36) 189 (45) 78 (19)
   P = 0.438 P = 0.459
Tumor size              
   pT1 686 280 (41) 289 (43) 109 (16) 209 (31) 340 (50) 131 (19)
   pT2 977 390 (40) 435 (45) 148 (15) 333 (34) 461 (47) 180 (18)
   pT3/4 200 78 (40) 83 (42) 36 (18) 74 (37) 103 (52) 22 (11)
   P = 0.789 P = 0.049
Grade              
   Poor 1007 403 (40) 437 (44) 162 (16) 326 (33) 508 (51) 168 (17)
   Good/moderate 282 113 (41) 120 (43) 44 (16) 101 (36) 122 (44) 56 (20)
   Unknown 574 232 (41) 250 (44) 87 (15) 189 (33) 274 (48) 109 (19)
   P = 0.994 P = 0.280
ER status              
   Positive 1367 529 (39) 606 (45) 219 (16) 445 (33) 666 (49) 249 (18)
   Negative 487 217 (45) 194 (40) 74 (15) 169 (35) 233 (48) 82 (17)
   P = 0.087 P = 0.625
PR status              
   Positive 1149 442 (39) 521 (46) 174 (15) 369 (32) 563 (49) 212 (19)
   Negative 601 267 (45) 232 (39) 99 (17) 207 (35) 290 (49) 99 (17)
   P = 0.018 P = 0.459
  1. 1Due to missing values the numbers do not always add up to 1863.
  2. 2All P values derived from Pearson's chi-squared statistics.
  3. xER = oestrogen receptor; PR = progesterone receptor.