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Table 3 Significant associations between the presence of DTC, serum DNA yields, LOH frequencies at the microsatellite markers and established risk factors determined by the Mann and Whitney-U test

From: Comparative evaluation of cell-free tumor DNA in blood and disseminated tumor cells in bone marrow of patients with primary breast cancer

 

Elevated

serum DNA

§LOH

complete

§LOH at D3S1255

§LOH at

D9S171 pos

$DTC

Age

     

< 55 years

     

> 55 years

no

no

no

P = 0.05

no

Tumor size

     

   pT1

     

   pT2-4

no

no

no

P < 0.05

no

Nodal status

     

   pN0

     

   pN1-2

no

no

no

no

no

Metastasis

     

   M0

     

   M1

no

no

no

no

P < 0.05

Histology

     

   Ductal

     

   Lobular

P < 0.03

P = 0.05

no

no

no

   others

     

Grading

     

   I-II

     

   III

no

P = 0.006

no

no

no

$DTC

     

   Positive

P < 0.05

no

no

no

 

   Negative

     

Recurrence

no

no

P < 0.05

P = 0.009*

P < 0.02

P = 0.001

no

  1. *Log rank test
  2. § loss of heterozygosity (LOH) detected in blood
  3. $ disseminated tumor cells (DTC) detected in bone marrow