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Table 1 Muc4 expression in human breast tissue by immunohistochemistry with 1G8s. Tissue samples from normal breast tissue, primary tumors or lymph node metastases were assigned a value of 0 to 3+ based on their MUC4 staining intensity with 1G8s. Statistical analysis of MUC4 staining intensities is presented for individual samples (upper panel) and patient-matched samples (lower panel).

From: The membrane mucin MUC4 is elevated in breast tumor lymph node metastases relative to matched primary tumors and confers aggressive properties to breast cancer cells

Tissue type - individual

Number of cases (%)a

Composite score (mean ± standard error)

Pvalue Norm vs Prim

Pvalue Prim vs Met

Normal

110 (92.4)

2.01 ± 0.09

< 0.001

 

Hyperplastic

26 (100)

   

Ductal carcinoma in situ

14 (85.7)

   

Primary tumorb

264 (79.5)

1.30 ± 0.06

  

Primary lobular carcinoma

22 (68.1)

   

Metastasis

48 (84)

1.63 ± 0.15

 

0.033

Tissue type - paired

Number of pairs

Composite score (mean ± standard error)

P values McNemar's test

 

Normal with matched primary

73

 

< 0.001

 

   Normal

 

2.07 ± 0.10

  

   Primary

 

1.28 ± 0.12

  

Primary with matched metastasisc

43

 

0.0025

 

   Primary

 

1.10 ± 0.21

  

   Metastasis

 

1.95 ± 0.41

  
  1. a. Percent of patient samples that had 1+ stain or greater on a scale from 0 to 3+.
  2. b. Primarily consists of invasive ductal carcinoma-NOS, but also includes invasive lobular carcinoma, micropapillary and mucinous carcinomas.