Table 2 Clinical and pathological data for breast tumours in the independent validation cohort

Median (interquartile range) tumour size (mm)

23.5 (17.75 to 35.0)

Histologic subtype

   Invasive ductal

80

   Invasive lobular

13

   Colloid/mucinous

1

   Tubular

1

   Tumour-associated normal

17

Intrinsic subtype

   Luminal A (ER/PR⁺, HER2/neu^-)

47

   Luminal B (ER/PR⁺, HER2/neu⁺)

21

   Her2 overexpressing (ER^-, PR^-, HER2/neu⁺)

11

   Triple-negative (ER^-, PR^-, HER2/neu^-)

11

   Missing data

5

Grade

   1

14

   2

26

   3

53

   Missing data

2

Nodal status

   Node-negative

50

   N1

17

   N2

17

   N3

11

Oestrogen receptor status

   Positive

62

   Negative

32

   Missing data

1

Progesterone receptor status

   Positive

58

   Negative

33

   Missing data

4

Her2/neu status

   Positive

32

   Negative

59

   Missing data

4

UICC stage

   Stage 1

23

   Stage 2a

29

   Stage 2b

8

   Stage 3a

14

   Stage 3b

4

   Stage 3c

8

   Stage 4

9