Table 4 Univariate analysis of 832 consecutive cases of breast carcinomas and 16 factors including classical histopronostic and immunohistochemical parameters

Hormonal therapy

0 (0%)

no

361 (43%)

1

0.000209

yes

471 (57%)

0.558 [0.408–0.763]

Age

1 (0%)

< 45 years

104 (13%)

1

0.673

>= 45 years

727 (87%)

1.1 [0.711–1.696]

< 45

104 (13%)

1

0.145

Tumor Size

7 (1%)

< 25 mm

381 (46%)

1

< 0.0001

>= 25 mm

444 (54%)

2.47 [1.719–3.562]

Scarff-Bloom-Richardson grade

22 (3%)

I

266 (33%)

1

< 0.0001

II–III

544 (67%)

3.69 [2.244–6.083]

VPI

4 (0%)

Absent

536 (65%)

1

< 0.0001

present

292 (35%)

2.1 [1.519–2.897]

Lymph node invasion

16 (2%)

N-

442 (54%)

1

< 0.0001

N+

374 (46%)

2.61 [1.693–4.013]

AR

175 (21%)

0

220 (33%)

1

0.0122

> 0

437 (67%)

0.65 [0.463–0.913]

< 80

410 (62%)

1

0.00422

>= 80

247 (38%)

0.568 [0.383–0.841]

BCL2

201 (24%)

0

162 (26%)

1

0.000944

> 0

469 (74%)

0.548 [0.381–0.787]

CCND1

142 (17%)

0

284 (41%)

1

0.562

> 0

406 (59%)

0.905 [0.647–1.268]

ERBB2

123 (15%)

0 or 1

621 (88%)

1

0.209

2 or 3

88 (12%)

1.33 [0.852–2.071]

FOXA1

187 (22%)

0

40 (6%)

1

0.324

> 0

605 (94%)

1.43 [0.698–2.952]

GATA3

188 (23%)

0

247 (38%)

1

0.00024

> 0

397 (62%)

0.534 [0.38–0.75]

Ki67

171 (21%)

< 20

560 (85%)

1

0.000748

>= 20

101 (15%)

1.96 [1.316–2.923]

P53

140 (17%)

0

525 (76%)

1

0.00095

> 0

167 (24%)

1.76 [1.253–2.47]

ER

79 (9%)

0

169 (22%)

1

0.000276

> 0

584 (78%)

0.54 [0.386–0.756]

PR

120 (14%)

0

263 (37%)

1

0.0875

> 0

449 (63%)

0.752 [0.542–1.044]