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Figure 3 | Breast Cancer Research

Figure 3

From: Recent advances in systemic therapy. New diagnostics and biological predictors of outcome in early breast cancer

Figure 3

Multifactorial regulation of topoisomerase IIa (TopoIIa). TopoIIa gene transcription is under control of gene signals and proliferative signals. Redox-sensitive protein complexes regulate mRNA half-life. Variable mRNA splicing produces protein isoforms: the cytoplasmic form is inactive, the nuclear form is active. Nuclear receptors regulate transport of these isoforms depending on the cell proliferative phase [43].

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