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Table 5 Cox univariate regression analyses of variables in relation to disease-free survival and overall survival

From: Determination of HER2 phosphorylation at tyrosine 1221/1222 improves prediction of poor survival for breast cancer patients with hormone receptor-positive tumors

Variable

Disease-free survival

Overall survival

 

P value

Relative risk (95% CI)

P value

Relative risk (95% CI)

Tumor grade

0.0201

1.767 (1.093 to 2.86)

0.0072

1.785 (1.170 to 2.725)

Tumor size

0.0007

2.070 (1.357 to 3.160)

0.0052

1.662 (1.164 to 2.375)

Nodal status

<0.0001

3.193 (2.091 to 4.876)

<0.0001

2.205 (1.545 to 3.148)

HER2

0.0037

2.470 (1.342 to 4.546)

0.0595

1.739 (0.978 to 3.093)

pHER1

0.0346

1.683 (1.038 to 2.726)

0.2317

1.309 (0.842 to 2.033)

pHER2

<0.0001

2.699 (1.662 to 4.384)

0.0002

2.273 (1.470 to 3.513)

pHER3

0.0489

1.686 (1.002 to 2.835)

0.3926

1.233 (0.763 to 1.995)

HER4

<0.0001

0.361 (0.238 to 0.549)

0.0111

0.624 (0.433 to 0.898)

  1. Variables were analyzed as follows: tumor grade (1 and 2 vs. 3), tumor size (<25 mm vs. ≥ 25 mm), nodal status (0 vs. ≥ 1), HER2 (negative vs. positive), pHER1 (negative vs. positive), pHER2 (negative and weak vs. strong), pHER3 (negative vs. positive), HER4 (low vs. high). 95% CI, 95% confidence interval. Bold data represent significant values.