Tumor grade | Tumor size | Nodal status | Recurrence | Death | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | 2 | 3 | <2 cm | 2 to 5 cm | >5 cm | 0 | 1 to 3 | ≥4 | No | Yes | No | Yes | |
HER2 | |||||||||||||
Negative | 61 | 96 | 49 | 78 | 149 | 19 | 22 | 137 | 87 | 169 | 77 | 137 | 109 |
Positive | 1 | 7 | 14 | 7 | 12 | 3 | 0 | 12 | 10 | 10 | 12 | 9 | 13 |
P value | 0.0003 (+) | 0.506 | 0.335 | 0.034 (+) | 0.190 | ||||||||
pHER1 | |||||||||||||
Negative | 50 | 82 | 49 | 62 | 136 | 19 | 16 | 125 | 76 | 150 | 67 | 121 | 196 |
Positive | 10 | 20 | 14 | 20 | 24 | 3 | 6 | 21 | 20 | 25 | 22 | 22 | 25 |
P value | 0.731 | 0.188 | 0.180 | 0.042 (+) | 0.333 | ||||||||
pHER2 | |||||||||||||
Negative | 43 | 57 | 24 | 49 | 92 | 14 | 12 | 88 | 55 | 105 | 50 | 91 | 64 |
Weak | 17 | 26 | 22 | 20 | 47 | 4 | 8 | 42 | 21 | 55 | 16 | 41 | 30 |
Strong | 1 | 19 | 17 | 12 | 22 | 4 | 2 | 16 | 20 | 16 | 22 | 12 | 26 |
P value | 0.0001 (+) | 0.811 | 0.189 | 0.001 (+) | 0.009 (+) | ||||||||
pHER3 | |||||||||||||
Negative | 50 | 88 | 50 | 69 | 134 | 18 | 20 | 123 | 78 | 153 | 68 | 122 | 99 |
Positive | 10 | 15 | 13 | 12 | 25 | 3 | 2 | 21 | 17 | 22 | 18 | 20 | 20 |
P value | 0.582 | 1.000 | 0.607 | 0.099 | 0.606 | ||||||||
HER4 | |||||||||||||
Low | 10 | 32 | 27 | 24 | 49 | 12 | 7 | 41 | 37 | 38 | 47 | 36 | 49 |
High | 51 | 67 | 35 | 56 | 109 | 10 | 13 | 105 | 57 | 133 | 42 | 104 | 71 |
P value | 0.004 (-) | 0.088 | 0.174 | <0.0001 (-) | 0.012 (-) | ||||||||
pErk | |||||||||||||
Negative | 20 | 45 | 35 | 32 | 72 | 9 | 12 | 57 | 44 | 76 | 37 | 63 | 50 |
Moderate | 13 | 25 | 11 | 18 | 40 | 3 | 4 | 33 | 24 | 42 | 19 | 32 | 29 |
Strong | 22 | 32 | 16 | 27 | 45 | 10 | 5 | 50 | 27 | 52 | 30 | 42 | 40 |
P value | 0.261 | 0.514 | 0.593 | 0.798 | 0.817 | ||||||||
pAkt | |||||||||||||
Negative | 10 | 29 | 20 | 20 | 46 | 4 | 8 | 33 | 29 | 48 | 22 | 42 | 28 |
Moderate | 30 | 34 | 26 | 38 | 59 | 9 | 9 | 54 | 43 | 64 | 42 | 58 | 48 |
Strong | 20 | 39 | 16 | 23 | 54 | 8 | 5 | 55 | 25 | 60 | 25 | 42 | 43 |
P value | 0.103 | 0.588 | 0.195 | 0.287 | 0.419 |