Skip to main content

Table 4 Protein expression levels in relation to clinicopathological properties

From: Determination of HER2 phosphorylation at tyrosine 1221/1222 improves prediction of poor survival for breast cancer patients with hormone receptor-positive tumors

 

Tumor grade

Tumor size

Nodal status

Recurrence

Death

 

1

2

3

<2 cm

2 to 5 cm

>5 cm

0

1 to 3

≥4

No

Yes

No

Yes

HER2

             

   Negative

61

96

49

78

149

19

22

137

87

169

77

137

109

   Positive

1

7

14

7

12

3

0

12

10

10

12

9

13

   P value

0.0003 (+)

0.506

0.335

0.034 (+)

0.190

pHER1

             

   Negative

50

82

49

62

136

19

16

125

76

150

67

121

196

   Positive

10

20

14

20

24

3

6

21

20

25

22

22

25

   P value

0.731

0.188

0.180

0.042 (+)

0.333

pHER2

             

   Negative

43

57

24

49

92

14

12

88

55

105

50

91

64

   Weak

17

26

22

20

47

4

8

42

21

55

16

41

30

   Strong

1

19

17

12

22

4

2

16

20

16

22

12

26

   P value

0.0001 (+)

0.811

0.189

0.001 (+)

0.009 (+)

pHER3

             

   Negative

50

88

50

69

134

18

20

123

78

153

68

122

99

   Positive

10

15

13

12

25

3

2

21

17

22

18

20

20

   P value

0.582

1.000

0.607

0.099

0.606

HER4

             

   Low

10

32

27

24

49

12

7

41

37

38

47

36

49

   High

51

67

35

56

109

10

13

105

57

133

42

104

71

   P value

0.004 (-)

0.088

0.174

<0.0001 (-)

0.012 (-)

pErk

             

   Negative

20

45

35

32

72

9

12

57

44

76

37

63

50

   Moderate

13

25

11

18

40

3

4

33

24

42

19

32

29

   Strong

22

32

16

27

45

10

5

50

27

52

30

42

40

   P value

0.261

0.514

0.593

0.798

0.817

pAkt

             

   Negative

10

29

20

20

46

4

8

33

29

48

22

42

28

   Moderate

30

34

26

38

59

9

9

54

43

64

42

58

48

   Strong

20

39

16

23

54

8

5

55

25

60

25

42

43

   P value

0.103

0.588

0.195

0.287

0.419

  1. Fisher's exact test was used to obtain the P values. (+) and (-), positive and negative correlations. Bold data represent significant values.