Table 6 Top 50 genes differentially expressed in invasive stroma compared to in situ stroma
From: Gene expression profiling of the tumor microenvironment during breast cancer progression
Probe set | Log2 (fold change) | Adjusted P value | Gene description |
|---|---|---|---|
Hs2.434299.1.S1_3p_at | 1.61 | 8.58 × 10-3 | - |
g13027795_3p_s_at | 1.45 | 1.74 × 10-2 | MMP11 – matrix metallopeptidase 11 (stromelysin 3) |
Hs.50081.1.S1_3p_a_at | 1.36 | 5.47 × 10-3 | KIAA1199 – KIAA1199 |
g11641276_3p_s_at | 1.24 | 3.71 × 10-2 | PDE4DIP – phosphodiesterase 4D interacting protein (myomegalin) |
Hs.169517.0.S1_3p_a_at | 1.16 | 5.72 × 10-3 | ALDH1B1 – aldehyde dehydrogenase 1 family, member B1 |
Hs.98523.0.A1_3p_at | 1.13 | 5.32 × 10-3 | FAT3 – FAT tumor suppressor homolog 3 (Drosophila) |
g10938018_3p_at | 1.04 | 1.74 × 10-2 | EPYC – epiphycan |
Hs2.350890.1.S1_3p_s_at | 1.03 | 3.72 × 10-2 | GABRB2 – gamma-aminobutyric acid (GABA) A receptor, beta 2 |
g4507922_3p_at | 0.98 | 1.70 × 10-2 | WISP2 – WNT1 inducible signaling pathway protein 2 |
g11342665_3p_at | 0.98 | 4.53 × 10-2 | MMP2 – matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72 kDa type IV collagenase) |
g13124890_3p_a_at | 0.93 | 3.28 × 10-2 | GALNT1 – UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1) |
Hs.98523.0.A1_3p_x_at | 0.87 | 3.15 × 10-2 | FAT3 – FAT tumor suppressor homolog 3 (Drosophila) |
Hs.238532.0.A1_3p_at | 0.76 | 3.71 × 10-2 | GALNTL2 – UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 2 |
Hs.42927.0.S1_3p_at | 0.75 | 3.39 × 10-2 | ANTXR1 – anthrax toxin receptor 1 |
Hs2.359399.1.S1_3p_at | 0.74 | 3.71 × 10-2 | LOC285758 – hypothetical protein LOC285758 |
Hs.235795.0.A1_3p_at | 0.74 | 1.38 × 10-2 | - |
Hs2.46679.2.S1_3p_s_at | 0.66 | 2.11 × 10-3 | - |
g469044_3p_a_at | 0.60 | 3.22 × 10-2 | CNTN1 – contactin 1 |
g4758607_3p_at | 0.53 | 1.20 × 10-2 | - |
Hs.288553.0.S1_3p_s_at | 0.52 | 2.82 × 10-2 | - |
200661_3p_at | 0.51 | 4.16 × 10-2 | CTSA – cathepsin A |
Hs.2399.1.S1_3p_s_at | 0.51 | 4.48 × 10-2 | MMP14 – matrix metallopeptidase 14 (membrane-inserted) |
Hs.98183.0.A1_3p_at | 0.48 | 8.58 × 10-3 | RSPO4 – R-spondin family, member 4 |
208756_3p_at | 0.48 | 2.28 × 10-2 | EIF3I – eukaryotic translation initiation factor 3, subunit I |
Hs.162647.0.S1_3p_at | 0.48 | 2.69 × 10-2 | DKFZP547L112 – hypothetical protein DKFZp547L112 |
Hs.22968.0.S1_3p_a_at | -2.00 | 8.37 × 10-6 | FLT1 – fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) |
g11545907_3p_at | -2.03 | 2.68 × 10-5 | ELTD1 – EGF, latrophilin and seven transmembrane domain containing 1 |
g5032094_3p_at | -2.03 | 3.64 × 10-7 | SLCO2A1 – solute carrier organic anion transporter family, member 2A1 |
Hs.8707.0.S1_3p_at | -2.07 | 1.29 × 10-5 | HECW2 – HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 |
Hs.134970.0.S1_3p_a_at | -2.07 | 6.66 × 10-3 | KIF26A – kinesin family member 26A |
Hs2.420404.1.S1_3p_at | -2.08 | 7.70 × 10-6 | PELO – pelota homolog (Drosophila) |
g4504850_3p_a_at | -2.11 | 3.62 × 10-2 | KCNK5 – potassium channel, subfamily K, member 5 |
Hs.288681.0.S1_3p_at | -2.13 | 4.98 × 10-4 | THSD7A – thrombospondin, type I, domain containing 7A |
g4557546_3p_at | -2.15 | 1.58 × 10-3 | EDNRB – endothelin receptor type B |
g11321596_3p_at | -2.19 | 1.64 × 10-3 | KDR – kinase insert domain receptor (a type III receptor tyrosine kinase) |
Hs.124675.0.A1_3p_at | -2.21 | 2.21 × 10-4 | GIMAP7 – GTPase, IMAP family member 7 |
Hs.211388.0.S1_3p_at | -2.24 | 5.72 × 10-3 | RUNDC3B – RUN domain containing 3B |
g4885556_3p_at | -2.25 | 2.13 × 10-3 | PODXL – podocalyxin-like |
Hs.26530.0.S2_3p_at | -2.30 | 1.60 × 10-3 | SDPR – serum deprivation response (phosphatidylserine binding protein) |
g13518036_3p_a_at | -2.41 | 7.19 × 10-3 | MATN2 – matrilin 2 |
Hs.102415.0.S1_3p_at | -2.43 | 2.67 × 10-8 | EMCN – endomucin |
Hs.61935.0.S1_3p_at | -2.45 | 2.68 × 10-5 | PCDH17 – protocadherin 17 |
g8547214_3p_at | -2.46 | 3.74 × 10-5 | EMCN – endomucin |
g4520327_3p_at | -2.48 | 2.67 × 10-3 | IL33 – interleukin 33 |
Hs.10587.0.S1_3p_at | -2.66 | 2.29 × 10-3 | DMN – desmuslin |
g3644039_3p_a_at | -2.67 | 1.43 × 10-2 | TP63 – tumor protein p63 |
Hs.78344.1.S2_3p_a_at | -2.87 | 2.13 × 10-3 | MYH11 – myosin, heavy chain 11, smooth muscle |
g6580814_3p_s_at | -2.93 | 8.90 × 10-5 | INMT – indolethylamine N-methyltransferase |
Hs.173560.0.S1_3p_at | -2.94 | 3.58 × 10-2 | ODZ2 – odz, odd Oz/ten-m homolog 2 (Drosophila) |
g4506870_3p_at | -3.23 | 1.80 × 10-3 | SELE – selectin E (endothelial adhesion molecule 1) |