Figure 4From: CD146 expression is associated with a poor prognosis in human breast tumors and with enhanced motility in breast cancer cell linesCD146 mRNA expression in human breast cancer cell lines. (a) Hierarchical clustering of 34 mammary cell lines and 13,976 genes/Expressed Sequence Tags based on mRNA expression levels. The legend is similar to Figure 2. Colored bars to the left, locations of four gene clusters of interest. The stromal/mesenchymal gene cluster (orange bar) includes MCAM. ER, estrogen receptor. (b) Dendrogram of cell lines. *Cell lines analyzed in the present study by flow cytometry for CD146 expression (low expression, MCF-7, ZR-75-30 and MDA-MB-453; high expression, MDA-MB-231, Hs578T and MCF-10A). (c) Expanded view of the stromal/mesenchymal gene cluster, which includes the four probe sets representing CD146/MCAM. Genes are referenced by their HUGO abbreviation as used in Entrez Gene.Back to article page