| Estrogen receptor-positive | Estrogen receptor-negative | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
Model | Mayo Clinic sample | SEARCH sample | Pooled Mayo Clinic + SEARCH sample | Mayo Clinic sample | SEARCH sample | Pooled Mayo Clinic + SEARCH sample | ||||
 | Cases/controls | OR (95% CI) | Cases/controls | OR (95% CI) | OR (95% CI) | Cases/controls | OR (95% CI) | Cases/controls | OR (95% CI) | OR (95% CI) |
General | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   0 copy | 340/661 | 1.0 (referent) | 1,506/3,506 | 1.0 (referent) | 1.0 (referent) | 86/661 | 1.0 (referent) | 344/3,506 | 1.0 (referent) | 1.0 (referent) |
   1 copy | 125/167 | 1.5 (1.1 to 1.9) | 431/980 | 1.0 (0.9 to 1.1) | 1.1 (0.9 to 1.2) | 20/167 | 0.9 (0.5 to 1.5) | 107/980 | 1.0 (0.8 to 1.4) | 1.0 (0.8 to 1.3) |
   2 copies | 17/13 | 2.5 (1.2 to 5.3) | 47/62 | 1.6 (1.0 to 2.5) | 1.9 (1.3 to 2.8) | 3/13 | 1.7 (0.4 to 6.5) | 5/62 | 0.8 (0.3 to 2.0) | 1.0 (0.5 to 2.2) |
P valuec | Â | 0.001 | Â | 0.10 | 0.001 | Â | 0.67 | Â | 0.79 | 0.98 |
Ordinal | Â | 1.5 (1.2 to 1.9) | Â | 1.1 (0.9 to 1.2) | 1.1 (1.0 to 1.3) | Â | 1.0 (0.7 to 1.6) | Â | 1.0 (0.8 to 1.3) | 1.0 (0.8 to 1.2) |
P trend | Â | 0.0003 | Â | 0.29 | 0.01 | Â | 0.89 | Â | 0.93 | 0.86 |