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Table 4 Gene-levela analysis of the decorin (DCN) and lumican (LUM) genes with breast cancer risk among 1,641 Caucasian subjectsb, Mayo Clinic 2001 to 2005

From: Genetic variation in stromal proteins decorin and lumican with breast cancer: investigations in two case-control studies

Gene/haplotype

Global haplotype score test P value

Estimated haplotype frequency

Individual haplotype score testc

Individual haplotype P valued

DCN e

0.18

   

   1a: AAAAC

 

0.73

-2.19

0.03

   1b: AGAAT

 

0.05

-0.65

0.52

   1c: GGAAC

 

0.001

0.38

0.70

   1d: AGAGT

 

0.12

0.59

0.55

   1e: AGGAC

 

0.004

0.82

0.41

   1f: AGAAC

 

0.03

1.82

0.07

   1g: GGGAC

 

0.07

1.92

0.05

LUM f

0.01

   

   2a: AGGGGA

 

0.71

-2.44

0.01

   2b: CGGGGA

 

0.05

-0.74

0.46

   2c: CGGGAA

 

0.004

-0.04

0.97

   2d: AACGAA

 

0.10

0.42

0.67

   2e: AGGGAA

 

0.003

0.89

0.37

   2f: CGGAAA

 

0.01

1.08

0.28

   2g: AGGAAA

 

0.003

1.38

0.17

   2h: AGCAAA

 

0.06

2.18

0.03

   2i: CGGAAG

 

0.07

2.29

0.02

  1. aAdjusted for age and region of residence (Minnesota, Iowa, Wisconsin, Illinois, North Dakota and South Dakota). b798 cases and 843 controls. cScore statistics comparing haplotype of interest with all other haplotypes combined. Negative values imply decreased risk of breast cancer, whereas positive values imply increased risk. dP value comparing haplotype of interest with all other haplotypes combined. eHaplotype-forming SNPs in DCN are rs7441 (A/G), rs516115 (A/G), rs3138165 (A/G), rs741212 (A/G), rs10492230 (A/G). fHaplotype-forming SNPs in LUM are rs1920790 (A/C), rs17714469 (G/A), rs10745553 (G/C), rs2268578 (G/A), rs10859110 (G/A), rs17018765 (A/G).