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Table 1 Genetic polymorphisms in the decorin (DCN) and lumican (LUM) genes and minor allele frequencies (MAFs) among 843 Caucasian controls, Mayo Clinic 2001 to 2005

From: Genetic variation in stromal proteins decorin and lumican with breast cancer: investigations in two case-control studies

Gene

Location

rsID

Polymorphic region

Amino acid change

MAF (controls)

DCN

12q21.33

rs7441

Ex8 G/A 3' UTR

 

0.06

  

rs3138268

Ex7 G/A

Met268Thr

0

  

rs516115

IVS3 A/G

 

0.26

  

rs3138165a

IVS1 G/A 5' UTR

 

0.06

  

rs2070985a

IVS1 G/C 5' UTR

 

0.06

  

rs741212

IVS1 A/G 5' UTR

 

0.12

  

rs13312816a

IVS1 A/T

 

0.06

  

rs10492230

G/A 5' upstream

 

0.16

LUM

12q21.3–q22

rs1920790

A/C 3' downstream

 

0.12

  

rs17714469

G/A 3' downstream

 

0.10

  

rs10745553

IVS2 G/C

 

0.15

  

rs2268578

IVS2 G/A

 

0.11

  

rs10859110

IVS1 G/A

 

0.22

  

rs17018765

A/G 5' upstream

 

0.06

  1. aLinkage disequilibrium r2 ≥ 0.98 for all pairwise combinations of these SNPs.