From: A functional Notch–survivin gene signature in basal breast cancer
Study | Total n | Subset | Survivin | Notch-1 | Keratin 5 | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Mean | SEM | P | Mean | SEM | P | Mean | SEM | P | |||
Chin and colleagues [55] | 118 | ER- (n = 43) | 0.7723 | 0.0815 | 1.353 × 10-5 | 0.7793 | 0.0548 | 2.231 × 10-5 | 0.9844 | 0.1436 | 4.893 × 10-6 |
ER+ (n = 75) | 0.3371 | 0.0437 | 0.5027 | 0.0245 | 0.1884 | 0.0678 | |||||
Desmedt and colleagues [56] | 198 | ER- (n = 64) | 0.7238 | 0.0478 | 1.414 × 10-8 | 0.3254 | 0.0389 | 3.951 × 10-4 | 0.6649 | 0.0996 | 1.159 × 10-2 |
ER+ (n = 134) | 0.3278 | 0.0460 | 0.1658 | 0.0193 | 0.3773 | 0.0507 | |||||
Ginestier and colleagues [57] | 55 | ER- (n = 28) | 0.7621 | 0.1251 | 9.689 × 10-5 | 1.4343 | 0.0504 | 2.933 × 10-4 | 1.2587 | 0.2116 | 1.219 × 10-2 |
ER+ (n = 27) | 0.4959 | 0.0954 | 1.1536 | 0.0520 | 0.5842 | 0.1492 | |||||
Hess and colleagues [58] | 133 | ER- (n = 51) | 0.0776 | 0.0451 | 2.071 × 10-3 | 0.2169 | 0.0454 | 1.203 × 10-1 | 0.5110 | 0.1706 | 1.165 × 10-4 |
ER+ (n = 82) | -0.0956 | 0.0309 | 0.1238 | 0.0384 | -0.2216 | 0.0480 | |||||
Ivshina and colleagues [59] | 249a | ER- (n = 34) | 0.4877 | 0.0847 | 1.064e × 10-7 | 0.3819 | 0.0589 | 1.643 × 10-2 | 0.7071 | 0.1683 | 1.403 × 10-1 |
ER+ (n = 211) | -0.0950 | 0.0408 | 0.2299 | 0.0137 | 0.4438 | 0.0479 | |||||
Miller and colleagues [60] | 251 | ER- (n = 34) | 0.3701 | 0.0681 | 2.780 × 10-8 | 0.3011 | 0.0443 | 2.073 × 10-2 | 0.4714 | 0.1310 | 2.638 × 10-1 |
ER+ (n = 213) | -0.1337 | 0.0382 | 0.1905 | 0.0113 | 0.3165 | 0.0389 | |||||
Minn and colleagues [61] | 82 | ER- (n = 42) | 0.1969 | 0.0719 | 1.809 × 10-4 | 0.4515 | 0.0529 | 7.897 × 10-5 | 1.1060 | 0.1311 | 2.391 × 10-6 |
ER+ (n = 57) | -0.1821 | 0.0652 | 0.2036 | 0.0247 | 0.2624 | 0.1028 | |||||
Richardson and colleagues [62] | 39 | ER- (n = 24) | -0.1141 | 0.1363 | 6.374 × 10-3 | 1.1360 | 0.0621 | 1.216 × 10-1 | 1.1878 | 0.1436 | 4.670e × 10-3 |
ER+ (n = 15) | -0.6187 | 0.1089 | 1.0139 | 0.0457 | 0.6193 | 0.1225 | |||||
Saal and colleagues [37] | 105 | ER- (n = 60) | -1.3798 | 0.1075 | 5.143 × 10-6 | 0.2043 | 0.0756 | 3.033 × 10-3 | |||
ER+ (n = 45) | -2.1290 | 0.1121 | -0.1145 | 0.0728 | |||||||
Sotiriou and colleagues [63] | 119 | ER- (n = 34) | 0.4834 | 0.0320 | 2.528 × 10-3 | 0.2702 | 0.0565 | 1.323 × 10-4 | 0.9849 | 0.1107 | 9.396 × 10-3 |
ER+ (n = 85) | 0.3691 | 0.0166 | 0.0181 | 0.0196 | 0.6560 | 0.0499 | |||||
Turashvili [32] | 10 | ER- (n = 3) | 0.1268 | 0.1688 | 2.533 × 10-1 | 1.1991 | 0.1243 | 3.082 × 10-1 | 0.6117 | 0.3735 | 6.750 × 10-1 |
ER+ (n = 7) | -0.2686 | 0.2733 | 1.0239 | 0.0709 | 0.3655 | 0.4358 | |||||
van de Vijver and colleagues [64] | 295 | ER- (n = 69) | 0.3719 | 0.2218 | 1.847 × 10-12 | 0.6277 | 0.1148 | 1.418 × 10-10 | -0.7917 | 0.4073 | 1.748 × 10-5 |
ER+ (n = 226) | -1.7301 | 0.1580 | -0.2900 | 0.0590 | -2.8083 | 0.1822 | |||||
Wang and colleagues [65] | 286 | ER- (n = 77) | 0.0902 | 0.0459 | 2.284 × 10-8 | 0.4139 | 0.0282 | 2.255 × 10-11 | 0.8906 | 0.0819 | 3.242 × 10-7 |
ER+ (n = 209) | -0.2387 | 0.0318 | 0.1784 | 0.0151 | 0.3844 | 0.0459 | |||||
Yu and colleagues [38] | 68 (19) | ER- (n = 15) | -0.2546 | 0.0874 | 1.689 × 10-1 | -0.2712 | 0.1090 | 1.946 × 10-4 | 1.8394* | 0.2312* | 2.280 × 10-2 * |
ER+ (n = 4) | -0.4225 | 0.0831 | 0.7625 | 0.0431 | 0.9196* | 0.2431* | |||||
Zhao and colleagues (lobular) [36] | 16 | ER- (n = 4) | -2.4418 | 0.2721 | 6.851 × 10-1 | 0.0416 | 0.4079 | 7.011 × 10-1 | |||
ER+ (n = 12) | -2.3108 | 0.1269 | -0.1367 | 0.1083 | |||||||
Zhao and colleagues (ductal) [36] | 34 | ER- (n = 11) | -1.4613 | 0.2938 | 1.440 × 10-1 | 0.3298 | 0.3722 | 1.769 × 10-1 | |||
ER+ (n = 23) | -2.0013 | 0.1981 | -0.2272 | 0.1104 |