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Figure 4 | Breast Cancer Research

Figure 4

From: ErbB3 is required for ductal morphogenesis in the mouse mammary gland

Figure 4

Immunohistochemical analysis of a TEB in serial sections. (a-d) TEBs from serial sections of an ErbB3+/+ gland 4 weeks after transplantation (panels a-d) have a typical single layer cap cell/myoepithelial cell outer layer (panels b and d) and a multilayered body cell section (panel c). (e-i, j-n, and o-s) Serial sections of three representative -/- TEBs at 4 weeks after transplantation. The three TEBs vary in the cap cell layer (panels h, l, and q), in the layers in the body cell layer (panels g, m, and d), and in the size of the spaces between the cap and body cell layers (panels i, j, and o). (t-w) The multilayered cap cell compartment has large spaces and the body cell layer is a single layer in the serial section of an ErbB3-/- TEB from a 7-week post-transplantation gland. cc3, cleaved caspase 3; H&E, hematoxylin and eosin; IgG, negative control antibody; E-cad, E-cadherin; P-cad, P-cadherin; SMA, smooth muscle actin; TEB, terminal end bud.

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