Skip to main content
Figure 7 | Breast Cancer Research

Figure 7

From: Heat shock protein-90-alpha, a prolactin-STAT5 target gene identified in breast cancer cells, is involved in apoptosis regulation

Figure 7

HSP90α promotes survival only in the presence of serum in SKBR3 breast cancer cells. Apoptosis was assessed by measuring the presence of mono- and oligo-nucleosomes as an indication of apoptosis (apoptotic index). Addition of 500 nM 17-allylamino-17-demethoxygeldanamycin (17-AAG) to SKBR3 cells increases apoptosis (t-test *p = 0.01). Starvation alone reduces the overall level of apoptosis observed in SKBR3 cells with serum (untr) (t-test p = 0.004). Each bar represents the average of three experiments with standard deviation. HSAP90α = heat shock protein 90 alpha.

Back to article page