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Table 8 The sensitivities, specificities, and positive and negative predictive values calculated with a Manchester Scoring System cut-off score of ≥ 10 for each gene and ≥ 15 combined, and for BOADICEA score of ≥ 0.10 for each gene and ≥ 0.10 combined (ie, 10% probability of carrying a deleterious mutation)

From: Evaluation of BRCA1 and BRCA2 mutations and risk-prediction models in a typical Asian country (Malaysia) with a relatively low incidence of breast cancer

 

Manchester Scoring System

BOADICEA

 

BRCA1

BRCA2

Combined

BRCA1

BRCA2

Combined

Area under the receiver operating curves

0.74

0.82

0.80

0.82

0.56

0.73

Standard error

0.078

0.079

0.06

0.070

0.093

0.061

95% CI

0.67 – 0.81

0.75 – 0.88

0.72 – 0.86

0.75 – 0.88

0.48 – 0.64

0.65 – 0.80

P value a

0.0018

0.0001

0.0001

0.0001

0.507

0.0001

Sensitivity

57%

55%

72%

57%

9%

40%

Specificity

76%

87%

74%

93%

93%

85%

Positive-predictive value

20%

25%

37%

47%

10%

36%

Negative-predictive value

94%

96%

93%

95%

93%

87%

  1. aP value is the probability that the sample area under the ROC curve is found when in fact, the true area under the ROC curve is 0.5 (i.e. null hypothesis: Area = 0.5).