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Volume 10 Supplement 3

Symposium Mammographicum 2008

  • Poster presentation
  • Open Access

Additional application of 1H-spectroscopic (3D-MRSI) and diffusion-weighted magnetic resonance imaging (MRI) in breast MRI at 3 T: is there a diagnostic value in comparison with high temporal and spatial resolution morphologic and dynamic MRI in patients with breast lesions?

  • 1,
  • 1,
  • 1,
  • 1,
  • 2,
  • 3,
  • 4 and
  • 1
Breast Cancer Research200810 (Suppl 3) :P65

  • Published:


  • Magnetic Resonance Imaging
  • Apparent Diffusion Coefficient
  • Breast Lesion
  • Breast Magnetic Resonance Imaging
  • Dynamic Magnetic Resonance Imaging


To assess the diagnostic accuracy of 1H-spectroscopic (3D-MRSI) and diffusion-weighted magnetic resonance imaging (DWI) in comparison with high-temporal and spatial resolution dynamic MRI in patients with breast lesions at 3 T.

Materials and methods

Thirty-six patients were examined on a 3 T system. The MRI protocol included: contrast-enhanced (CE) coronal volumetric interpolated breathhold examination with high-temporal resolution (isotropic 1.7 mm, time of acquisition (TA) 11.7 seconds, 17 measurements); coronal magnetization prepared rapid gradient echo at expected maximum CE (1 mm isotropic, TA 2.03 minutes), repeated coronal volumetric interpolated breathhold examination, diffusion-weighted imaging using a twice-refocused singleshot echo planar imaging sequence with inversion recovery fat-saturation employing four b values (TA 4.48 minutes), 3D-MRSI (10 × 10 × 10 mm3; TA 11 minutes). The lesion morphology and CE kinetics were assessed. Regions of interest for suspicious areas were evaluated for elevated choline levels and decreased apparent diffusion coefficient values as a marker of malignancy.


Sixty-five lesions were detected in 36 patients. CE-MRI determined 11 lesions, DWI 11 lesions and 3D-MRSI 11 lesions (one false positive, one false negative) as malignant. CE-MRI determined 48 lesions, DWI 54 lesions and 3D-MRSI 49 lesions as benign. 3D-MRSI was not applicable in five prepectoral lesions. CE-MRI determined six lesions as indifferent, which were benign with DWI and 3D-MRSI.


The performance of dynamic MRI and additional DWI and 3D-MRSI is possible within reasonable scan time, and additional DWI and 3D-MRSI aid the differentiation of breast lesions with indifferent morphology and/or CE kinetics.

Authors’ Affiliations

MR Centre of Excellence, Department of Radiology, Medical University Vienna, Austria
Department of Imaging Methods, Institute of Measurement Science, Slovak Academy of Sciences, Bratislava, Slovakia
Department of Medical Imaging, University of Toronto, Canada
Department of Radiology, Medical University Vienna, Austria


© BioMed Central Ltd 2008