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Ultrasound-guided axillary node core biopsy in the staging of newly diagnosed breast cancer
Breast Cancer Research volume 10, Article number: P17 (2008)
One hundred and thirty-nine patients with core biopsy (CB)-proven unilateral primary operable invasive breast cancer underwent axillary ultrasound. Lymph nodes were identified on ultrasound in 134 patients (96%), of which 121 (87%) underwent core biopsy. The morphology of all biopsied nodes was noted. Normal lymph node was obtained in 77 CBs, 25 (32%) of which were subsequently shown to have nodal metastases. The results are presented in Table 1. The CB sensitivity for nodes with normal ultrasound morphology was 12%, for those with unilobulated cortex was 64%, for those with multilobulated cortex was 77%, for those with absent hilum was 88% and for those with multilobulated cortex and absent hilum was 100%.
In conclusion, the present study shows that an aggressive CB policy leads to an increase in sensitivity, but of relatively modest proportions, and is at the expense of a large number of normal biopsies. CB is insensitive at detecting micrometastases. CB of nodes with a normal ultrasound morphology is of little utility.
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Britton, P., Goud, A., Barter, S. et al. Ultrasound-guided axillary node core biopsy in the staging of newly diagnosed breast cancer. Breast Cancer Res 10, P17 (2008) doi:10.1186/bcr2015
- Breast Cancer
- Lymph Node
- Nodal Metastasis
- Cancer Research
- Axillary Node