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Table 1 Limiting dilution tumor formation of CD44+/CD24-/low/ESA+ sorted cells in vivo

From: Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypically diverse progeny and survive chemotherapy

Cell type

Days

Number injected and tumors formed

  

1 × 106

1 × 105

1 × 104

1 × 103

1 × 102

SUM159 unsorted

13–100

5/5

5/6

5/8

3/8

0/2

SUM159 CD44+/CD24-/ESA-

20–100

8/10

2/2

1/2

0/8

0/10

SUM159 CD44+/CD24-/low/ESA+

20–100

-

-

2/2

6/6

6/10

SUM1315 unsorted

20–150

2/2

2/2

2/4

0/4

-

SUM1315 CD44+/CD24-/ESA-

25–150

3/4

2/2

0/4

0/10

-

SUM1315 CD44+/CD24-/low/ESA+

20–150

-

-

3/4

7/8

-

SUM149 unsorted

19–150

4/4

3/4

2/4

1/4

0/2

SUM149 CD44+/CD24+/ESA+

20–150

-

2/2

0/4

0/4

0/6

SUM149 CD44+/CD24-/low/ESA+

48–150

-

2/2

2/4

6/6

5/6

  1. ESA, epithelial-specific antigen.