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Table 3 Summary of diet effects on leptin and apoptosis signaling protein and mRNA expression levels

From: Effects of high-fat diet and/or body weight on mammary tumor leptin and apoptosis signaling pathways in MMTV-TGF-α mice

 

MT

MFP

Leptin signaling molecules

    

   Leptin

NC

NC

NC

   ObR

NC

NC

   ObRb

   Jak2

NM

NM

   pSTAT3

NC

NC

Apoptosis signaling molecules

    

   PARP (total)

 

 

   PARP (89 kDa)

 

NC

 

   PARP (24 kDa)

 

NC

 

   Caspase-3 activity

 

 

   Bax

NC

 

 

   Bcl-2

NC

 

NC

 

   Bcl-XL

 

 

   pAkt

NC

 

NC

 
  1. Jak2, Janus kinase 2; MFP, mammary fat pad; MT, mammary tumor; NC, no statistically significant change; NM, not measured; pAkt, phosphorylated Akt; PARP, poly(ADP-ribose)polymerase; pSTAT3, phosphorylated signal transducer and activator of transcription 3. Solid arrows show protein expression and dashed lines mRNA expression.
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Breast Cancer Research

ISSN: 1465-542X

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