Table 5 Correlation analysis of hypoxia-inducible factor 1α (HIF-1α) expression and standard clinicopathological parameters
|  | HIF-1α-positive (n = 125) | HIF-1α-negative (n = 91) | P value |
|---|---|---|---|
Median patient age (years) | 59 | 59 | 0.59 |
Median tumour size (mm) | 20 | 20 | 0.23 |
Tumour grade | Â | Â | 0.52 |
   1 | 22 | 15 |  |
   2 | 44 | 22 |  |
   3 | 27 | 23 |  |
Nodal status | Â | Â | 0.02 |
   Negative | 62 | 31 |  |
   Positive | 63 | 60 |  |
Oestrogen receptor status | Â | Â | 0.90 |
   Negative | 98 | 72 |  |
   Positive | 27 | 19 |  |
Human epidermal growth factor receptor 2 status | Â | Â | 0.77 |
   Negative | 12 | 11 |  |
   Positive | 87 | 70 |  |