| Exclusive nuclear FIH-1 expression (n = 42) | Nuclear and cytoplasmic FIH-1 expression (n = 143) | Exclusive cytoplasmic FIH-1 expression (n = 54) | Nuclear and cytoplasmic FIH-1-negative (n = 56) |
---|---|---|---|---|
Median patient age (years) | 57 | 56 | 58 | 56 |
Median tumour size (mm) | 18 | 20 | 25 | 20 |
Tumour grade | Â | Â | Â | Â |
   1 | 12 | 24 | 3 | 8 |
   2 | 12 | 43 | 17 | 15 |
   3 | 8 | 35 | 21 | 12 |
Nodal status | Â | Â | Â | Â |
   Negative | 23 | 77 | 32 | 35 |
   Positive | 19 | 64 | 22 | 20 |
Oestrogen receptor status | Â | Â | Â | Â |
   Negative | 8 | 30 | 14 | 20 |
   Positive | 34 | 113 | 40 | 35 |
Human epidermal growth factor receptor 2 status | Â | Â | Â | Â |
   Negative | 25 | 95 | 43 | 23 |
   Positive | 3 | 17 | 6 | 2 |
Hypoxia-inducible factor 1α |  |  |  |  |
   Negative | 10 | 41 | 25 | 22 |
   Positive | 32 | 82 | 28 | 20 |
Carbonic anhydrase 9 | Â | Â | Â | Â |
   Negative | 34 | 111 | 33 | 22 |
   Positive | 3 | 14 | 11 | 4 |
Recurrence | Â | Â | Â | Â |
   Negative | 32 | 88 | 28 | 37 |
   Positive | 9 | 54 | 26 | 18 |