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Figure 7 | Breast Cancer Research

Figure 7

From: Anticlusterin treatment of breast cancer cells increases the sensitivities of chemotherapy and tamoxifen and counteracts the inhibitory action of dexamethasone on chemotherapy-induced cytotoxicity

Figure 7

Effects of dexamethasone pretreatment on chemotherapy-induced cytotoxicity. (a) Dexamethasone pretreatment (10-7 M) inhibits chemotherapy-induced cytotoxicity in the MCF-7 cell line. (b) However, clusterin antisense oligonucleotides (ODNclu) increase chemotherapy-induced cytotoxicity in the presence of dexamethasone. Cells were treated with dexamethasone for 4 hours. After dexamethasone treatment, the medium was replaced in some wells with medium containing 10-7 M paclitaxel or doxorubicin for 1 day. Cell viability was determined by trypan blue exclusion test. Each data point represents the mean percentages of at least three independent experiments ± standard error of the mean. *p < 0.05; **p < 0.01; ***p < 0.001. Differences between treatment with chemotherapeutic agents and treatment with dexamethasone alone or dexamethasone plus chemotherapeutic agents are shown in (a). D, doxorubicin; ODNc, control oligonucleotide; P, paclitaxel.

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Breast Cancer Research

ISSN: 1465-542X

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