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Table 3 Odds ratios and 95% confidence intervals for breast cancer risk associated with BsmI and Poly(A) genotypes, stratified by race and menopausal status

From: Vitamin D receptor polymorphisms and breast cancer risk in a large population-based case-control study of Caucasian and African-American women

Genotype

 

Menopausal status

Caucasian

African-American

   

Case (%)

Control (%)

ORa (95% CI)

Case (%)

Control (%)

ORa (95% CI)

BsmI

B/B

Premenopausal

164 (25.3)

133 (25.8)

1.0 (referent)

38 (12.1)

22 (9.6)

1.0 (referent)

 

B/b

 

244 (36.9)

198 (36.0)

1.1 (0.8 to 1.5)

108 (34.6)

90 (36.7)

0.8 (0.4 to 1.4)

 

b/b

 

247 (37.8)

199 (38.1)

1.0 (0.7 to 1.4)

156 (53.3)

126 (53.7)

0.8 (0.4 to 1.5)

 

Any b

 

491 (74.7)

397 (74.2)

1.0 (0.8 to 1.4)

264 (87.9)

216 (90.4)

0.8 (0.4 to 1.4)

 

B/B

Postmenopausal

114 (23.5)

125 (29.2)

1.0 (referent)

29 (15.2)

28 (14.3)

1.0 (referent)

 

B/b

 

188 (39.3)

173 (40.9)

1.2 (0.8 to 1.8)

66 (38.0)

78 (34.0)

1.0 (0.5 to 2.0)

 

b/b

 

179 (37.2)

137 (30.0)

1.5 (1.0 to 2.3)b

88 (46.8)

102 (51.7)

0.9 (0.5 to 2.0)

 

Any b

 

367 (76.5)

310 (70.8)

1.4 (1.0 to 1.9)

154 (84.8)

180 (85.7)

1.0 (0.5 to 1.8)

Poly(A)

S/S

Premenopausal

98 (15.7)

79 (15.4)

1.0 (referent)

23 (9.1)

14 (6.8)

1.0 (referent)

 

L/S

 

303 (45.3)

260 (47.3)

0.9 (0.6 to 1.4)

109 (39.6)

88 (39.2)

0.8 (0.4 to 1.7)

 

L/L

 

256 (39)

203 (37.3)

1.0 (0.7 to 1.5)

144 (51.3)

118 (54.1)

0.7 (0.3 to 1.6)

 

Any L

 

559 (84.3)

463 (84.6)

1.0 (0.7 to 1.4)

253 (90.9)

206 (93.3)

0.7 (0.4 to 1.6)

 

S/S

Postmenopausal

69 (14.5)

70 (15.8)

1.0 (referent)

12 (8.5)

13 (6.8)

1.0 (referent)

 

L/S

 

229 (47.2)

222 (52.2)

1.0 (0.7 to 1.6)

72 (41.9)

81 (38.9)

0.8 (0.3 to 2.1)

 

L/L

 

184 (38.3)

151 (31.9)

1.3 (0.9 to 2.1)

81 (49.5)

103 (54.3)

0.8 (0.3 to 2.1)

 

Any L

 

413 (85.5)

373 (84.2)

1.2 (0.8 to 1.8)

153 (91.5)

184 (93.2)

0.8 (0.3 to 2.0)

  1. aOdds ratio (OR) adjusted for age, race, study site, and sampling weights. bP for trend <0.05.