Figure 2From: The oestrogen paradox: an hypothesisEffect of oestradiol on apoptosis in wild type and long-term oestradiol-deprived cells. (a) Long-term oestradiol deprived (LTED) MCF7 cells respond to oestradiol (E2) with an increase in apoptosis, whereas (b) wild type MCF7 cells respond to the same dose of oestradiol with a reduction in apoptosis. Reproduced with permission from Oxford University Press from Song RX, Mor G, Naftolin F, McPherson RA, Song J, Zhang Z, Yue W, Wang J, Santen RJ: Effect of long-term estrogen deprivation on apoptotic responses of breast cancer cells to 17beta-estradiol. J Natl Cancer Inst 2001, 93:1714–1723.Back to article page